Cell type atlas - PPIH - The Human Protein Atlas

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PPIH

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPIH
Gene descriptionⁱ Full gene name according to HGNC.	Peptidylprolyl isomerase H
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	42 NX
Kidney	58 NX
Colon	33 NX
Liver	26 NX

Basal glandular cells	38 NX
Prostate	38 NX

Basal keratinocytes	26 NX
Skin	26 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	54 NX
Placenta	54 NX

Distal tubular cells	38 NX
Kidney	38 NX

Ductal cells	24 NX
Pancreas	24 NX

Early spermatids	20 NX
Testis	20 NX

Endothelial cells	18 NX
Placenta	38 NX
Pancreas	36 NX
Liver	32 NX
Testis	28 NX
Eye	20 NX
Lung	18 NX
Prostate	16 NX
Skin	15 NX
Heart muscle	14 NX

Enterocytes	12 NX
Small intestine	13 NX
Rectum	12 NX
Colon	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	23 NX
Pancreas	23 NX

Extravillous trophoblasts	87 NX
Placenta	87 NX

Fibroblasts	17 NX
Placenta	38 NX
Skin	17 NX
Prostate	14 NX
Heart muscle	10 NX
Lung	8 NX

Glandular cells	22 NX
Prostate	22 NX

Granulocytes	30 NX
Lung	33 NX
Colon	28 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	5 NX
Eye	5 NX

Intestinal endocrine cells	21 NX
Colon	27 NX
Rectum	14 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	15 NX
Liver	15 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	27 NX
Testis	27 NX

Macrophages	27 NX
Pancreas	47 NX
Testis	36 NX
Prostate	35 NX
Kidney	26 NX
Lung	25 NX
Skin	25 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	26 NX
Colon	29 NX
Rectum	28 NX
Small intestine	14 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	22 NX
Pancreas	22 NX

Paneth cells	18 NX
Rectum	28 NX
Small intestine	18 NX
Colon	3 NX

Peritubular cells	20 NX
Testis	20 NX

Proximal tubular cells	25 NX
Kidney	25 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	17 NX
Pancreas	43 NX
Prostate	17 NX
Skin	16 NX
Heart muscle	13 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	32 NX
Placenta	32 NX

T-cells	42 NX
Kidney	54 NX
Liver	47 NX
Lung	39 NX
Colon	34 NX
Skin	28 NX
Prostate	18 NX

Undifferentiated cells	32 NX
Small intestine	39 NX
Rectum	31 NX
Colon	26 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.