Cell type atlas - PRNP - The Human Protein Atlas

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PRNP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRNP
Gene descriptionⁱ Full gene name according to HGNC.	Prion protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal keratinocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (WM-115)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal keratinocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	75 NX
Lung	75 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	34 NX
Colon	176 NX
Kidney	54 NX
Liver	7 NX

Basal glandular cells	182 NX
Prostate	182 NX

Basal keratinocytes	367 NX
Skin	367 NX

Bipolar cells	231 NX
Eye	231 NX

Cardiomyocytes	189 NX
Heart muscle	189 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	110 NX
Eye	110 NX

Cytotrophoblasts	6 NX
Placenta	6 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	47 NX
Skin	163 NX
Prostate	146 NX
Placenta	63 NX
Eye	48 NX
Lung	47 NX
Liver	41 NX
Testis	29 NX
Pancreas	25 NX
Heart muscle	23 NX

Enterocytes	2 NX
Colon	3 NX
Small intestine	2 NX
Rectum	2 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	13 NX
Pancreas	13 NX

Extravillous trophoblasts	6 NX
Placenta	6 NX

Fibroblasts	172 NX
Prostate	357 NX
Skin	232 NX
Heart muscle	172 NX
Lung	122 NX
Placenta	43 NX

Glandular cells	80 NX
Prostate	80 NX

Granulocytes	169 NX
Colon	175 NX
Lung	163 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	58 NX
Placenta	58 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	29 NX
Colon	34 NX
Rectum	23 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	185 NX
Liver	184 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	133 NX
Testis	133 NX

Macrophages	109 NX
Prostate	253 NX
Skin	150 NX
Testis	108 NX
Lung	99 NX
Kidney	73 NX
Pancreas	16 NX

Melanocytes	160 NX
Skin	160 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	14 NX
Pancreas	14 NX

Mucus-secreting cells	5 NX
Rectum	6 NX
Small intestine	4 NX
Colon	2 NX

Muller glia cells	133 NX
Eye	133 NX

Pancreatic endocrine cells	17 NX
Pancreas	17 NX

Paneth cells	3 NX
Rectum	9 NX
Colon	3 NX
Small intestine	0 NX

Peritubular cells	160 NX
Testis	160 NX

Proximal tubular cells	70 NX
Kidney	70 NX

Rod photoreceptor cells	79 NX
Eye	79 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	125 NX
Prostate	207 NX
Skin	174 NX
Pancreas	81 NX
Heart muscle	46 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	249 NX
Skin	249 NX

Syncytiotrophoblasts	12 NX
Placenta	12 NX

T-cells	52 NX
Skin	335 NX
Prostate	275 NX
Colon	96 NX
Kidney	60 NX
Lung	48 NX
Liver	22 NX

Undifferentiated cells	7 NX
Small intestine	10 NX
Rectum	7 NX
Colon	7 NX

Urothelial cells	105 NX
Prostate	105 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.