Cell type atlas - PTEN - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PTEN

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PTEN
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatase and tensin homolog
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	55 NX
Lung	55 NX

B-cells	40 NX
Kidney	45 NX
Liver	40 NX
Colon	31 NX

Basal glandular cells	50 NX
Prostate	50 NX

Basal keratinocytes	50 NX
Skin	50 NX

Bipolar cells	113 NX
Eye	113 NX

Cardiomyocytes	39 NX
Heart muscle	39 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	37 NX
Eye	37 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	28 NX
Kidney	28 NX

Ductal cells	23 NX
Pancreas	23 NX

Early spermatids	57 NX
Testis	57 NX

Endothelial cells	44 NX
Eye	163 NX
Heart muscle	52 NX
Testis	50 NX
Skin	46 NX
Liver	45 NX
Prostate	44 NX
Placenta	34 NX
Lung	20 NX
Pancreas	7 NX

Enterocytes	34 NX
Rectum	74 NX
Small intestine	42 NX
Colon	29 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	45 NX
Placenta	45 NX

Fibroblasts	52 NX
Skin	73 NX
Prostate	61 NX
Heart muscle	52 NX
Placenta	30 NX
Lung	24 NX

Glandular cells	37 NX
Prostate	37 NX

Granulocytes	25 NX
Colon	37 NX
Lung	14 NX

Hepatocytes	59 NX
Liver	59 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	30 NX
Rectum	33 NX
Colon	27 NX

Ito cells	48 NX
Liver	48 NX

Kupffer cells	167 NX
Liver	167 NX

Late spermatids	71 NX
Testis	71 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	69 NX
Prostate	154 NX
Testis	91 NX
Skin	77 NX
Lung	58 NX
Kidney	54 NX
Pancreas	40 NX

Melanocytes	59 NX
Skin	59 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	44 NX
Rectum	55 NX
Small intestine	39 NX
Colon	27 NX

Muller glia cells	54 NX
Eye	54 NX

Pancreatic endocrine cells	30 NX
Pancreas	30 NX

Paneth cells	25 NX
Rectum	63 NX
Small intestine	25 NX
Colon	20 NX

Peritubular cells	51 NX
Testis	51 NX

Proximal tubular cells	31 NX
Kidney	31 NX

Rod photoreceptor cells	56 NX
Eye	56 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	119 NX
Heart muscle	151 NX
Prostate	140 NX
Skin	117 NX
Pancreas	65 NX

Spermatocytes	25 NX
Testis	25 NX

Spermatogonia	24 NX
Testis	24 NX

Suprabasal keratinocytes	53 NX
Skin	53 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	36 NX
Prostate	48 NX
Liver	45 NX
Skin	44 NX
Kidney	36 NX
Colon	35 NX
Lung	23 NX

Undifferentiated cells	39 NX
Rectum	51 NX
Small intestine	37 NX
Colon	22 NX

Urothelial cells	51 NX
Prostate	51 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.