Cell type atlas - HDAC3 - The Human Protein Atlas

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HDAC3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HDAC3
Gene descriptionⁱ Full gene name according to HGNC.	Histone deacetylase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	10 NX
Lung	10 NX

B-cells	32 NX
Colon	42 NX
Kidney	36 NX
Liver	21 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	57 NX
Eye	57 NX

Cytotrophoblasts	47 NX
Placenta	47 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	20 NX
Pancreas	29 NX
Skin	25 NX
Placenta	23 NX
Prostate	21 NX
Testis	20 NX
Eye	19 NX
Lung	18 NX
Liver	14 NX
Heart muscle	13 NX

Enterocytes	15 NX
Rectum	21 NX
Small intestine	17 NX
Colon	11 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	31 NX
Pancreas	31 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	29 NX
Placenta	39 NX
Skin	30 NX
Lung	22 NX
Prostate	19 NX
Heart muscle	19 NX

Glandular cells	19 NX
Prostate	19 NX

Granulocytes	18 NX
Colon	28 NX
Lung	9 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	35 NX
Placenta	35 NX

Horizontal cells	48 NX
Eye	48 NX

Intestinal endocrine cells	17 NX
Colon	20 NX
Rectum	14 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	15 NX
Liver	15 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	33 NX
Pancreas	63 NX
Prostate	41 NX
Skin	38 NX
Testis	32 NX
Kidney	26 NX
Lung	13 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	67 NX
Pancreas	67 NX

Mucus-secreting cells	18 NX
Rectum	18 NX
Small intestine	18 NX
Colon	16 NX

Muller glia cells	28 NX
Eye	28 NX

Pancreatic endocrine cells	27 NX
Pancreas	27 NX

Paneth cells	14 NX
Rectum	25 NX
Small intestine	14 NX
Colon	6 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	24 NX
Pancreas	34 NX
Skin	28 NX
Prostate	19 NX
Heart muscle	15 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	51 NX
Placenta	51 NX

T-cells	32 NX
Liver	36 NX
Colon	35 NX
Kidney	32 NX
Skin	31 NX
Lung	23 NX
Prostate	13 NX

Undifferentiated cells	23 NX
Small intestine	28 NX
Rectum	23 NX
Colon	20 NX

Urothelial cells	27 NX
Prostate	27 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.