Cell type atlas - CLSTN1 - The Human Protein Atlas

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CLSTN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CLSTN1
Gene descriptionⁱ Full gene name according to HGNC.	Calsyntenin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	15 NX
Lung	15 NX

B-cells	19 NX
Colon	19 NX
Kidney	18 NX
Liver	11 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	199 NX
Eye	199 NX

Cardiomyocytes	11 NX
Heart muscle	11 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	40 NX
Lung	40 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	49 NX
Kidney	49 NX

Cone photoreceptor cells	412 NX
Eye	412 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	31 NX
Placenta	47 NX
Liver	41 NX
Eye	36 NX
Lung	32 NX
Testis	31 NX
Heart muscle	25 NX
Skin	21 NX
Prostate	19 NX
Pancreas	7 NX

Enterocytes	112 NX
Rectum	231 NX
Colon	139 NX
Small intestine	51 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	12 NX
Placenta	12 NX

Fibroblasts	33 NX
Placenta	37 NX
Skin	30 NX
Heart muscle	27 NX
Prostate	19 NX
Lung	18 NX

Glandular cells	56 NX
Prostate	56 NX

Granulocytes	12 NX
Colon	18 NX
Lung	5 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	170 NX
Eye	170 NX

Intestinal endocrine cells	30 NX
Rectum	42 NX
Colon	17 NX

Ito cells	34 NX
Liver	34 NX

Kupffer cells	22 NX
Liver	22 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	43 NX
Testis	43 NX

Macrophages	12 NX
Testis	22 NX
Kidney	18 NX
Skin	16 NX
Pancreas	12 NX
Lung	12 NX
Prostate	8 NX

Melanocytes	30 NX
Skin	30 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	21 NX
Pancreas	21 NX

Mucus-secreting cells	87 NX
Rectum	89 NX
Colon	85 NX
Small intestine	80 NX

Muller glia cells	156 NX
Eye	156 NX

Pancreatic endocrine cells	43 NX
Pancreas	43 NX

Paneth cells	52 NX
Colon	86 NX
Rectum	52 NX
Small intestine	42 NX

Peritubular cells	47 NX
Testis	47 NX

Proximal tubular cells	26 NX
Kidney	26 NX

Rod photoreceptor cells	135 NX
Eye	135 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	21 NX
Pancreas	29 NX
Prostate	23 NX
Skin	19 NX
Heart muscle	12 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	37 NX
Testis	37 NX

Suprabasal keratinocytes	23 NX
Skin	23 NX

Syncytiotrophoblasts	16 NX
Placenta	16 NX

T-cells	25 NX
Prostate	31 NX
Kidney	29 NX
Colon	25 NX
Liver	25 NX
Skin	18 NX
Lung	14 NX

Undifferentiated cells	48 NX
Rectum	61 NX
Colon	60 NX
Small intestine	29 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.