Cell type atlas - PPID - The Human Protein Atlas

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PPID

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPID
Gene descriptionⁱ Full gene name according to HGNC.	Peptidylprolyl isomerase D
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	12 NX
Lung	12 NX

B-cells	19 NX
Colon	31 NX
Kidney	22 NX
Liver	8 NX

Basal glandular cells	25 NX
Prostate	25 NX

Basal keratinocytes	9 NX
Skin	9 NX

Bipolar cells	25 NX
Eye	25 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	76 NX
Lung	76 NX

Club cells	33 NX
Lung	33 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	33 NX
Placenta	33 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	35 NX
Pancreas	35 NX

Early spermatids	24 NX
Testis	24 NX

Endothelial cells	26 NX
Pancreas	54 NX
Prostate	34 NX
Heart muscle	30 NX
Placenta	29 NX
Testis	26 NX
Liver	16 NX
Lung	12 NX
Skin	12 NX
Eye	11 NX

Enterocytes	19 NX
Small intestine	33 NX
Rectum	16 NX
Colon	12 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	20 NX
Pancreas	20 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	21 NX
Heart muscle	34 NX
Prostate	31 NX
Lung	31 NX
Placenta	22 NX
Skin	13 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	31 NX
Lung	35 NX
Colon	28 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	37 NX
Placenta	37 NX

Horizontal cells	72 NX
Eye	72 NX

Intestinal endocrine cells	19 NX
Colon	31 NX
Rectum	7 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	16 NX
Testis	16 NX

Leydig cells	19 NX
Testis	19 NX

Macrophages	22 NX
Prostate	36 NX
Testis	34 NX
Lung	23 NX
Kidney	21 NX
Skin	16 NX
Pancreas	12 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	63 NX
Pancreas	63 NX

Mucus-secreting cells	23 NX
Colon	32 NX
Rectum	22 NX
Small intestine	20 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	27 NX
Pancreas	27 NX

Paneth cells	22 NX
Small intestine	42 NX
Rectum	22 NX
Colon	12 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	25 NX
Kidney	25 NX

Rod photoreceptor cells	25 NX
Eye	25 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	30 NX
Pancreas	45 NX
Prostate	33 NX
Heart muscle	30 NX
Skin	17 NX

Spermatocytes	79 NX
Testis	79 NX

Spermatogonia	76 NX
Testis	76 NX

Suprabasal keratinocytes	10 NX
Skin	10 NX

Syncytiotrophoblasts	40 NX
Placenta	40 NX

T-cells	27 NX
Colon	47 NX
Lung	30 NX
Kidney	27 NX
Liver	23 NX
Prostate	18 NX
Skin	13 NX

Undifferentiated cells	24 NX
Colon	37 NX
Small intestine	36 NX
Rectum	21 NX

Urothelial cells	17 NX
Prostate	17 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.