Cell type atlas - INSR - The Human Protein Atlas

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INSR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INSR
Gene descriptionⁱ Full gene name according to HGNC.	Insulin receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Disease related genes Enzymes FDA approved drug targets Plasma proteins RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	8 NX
Liver	16 NX
Kidney	9 NX
Colon	7 NX

Basal glandular cells	55 NX
Prostate	55 NX

Basal keratinocytes	58 NX
Skin	58 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	85 NX
Heart muscle	85 NX

Cholangiocytes	107 NX
Liver	107 NX

Ciliated cells	42 NX
Lung	42 NX

Club cells	50 NX
Lung	50 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	75 NX
Eye	75 NX

Cytotrophoblasts	16 NX
Placenta	16 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	41 NX
Pancreas	41 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	52 NX
Prostate	291 NX
Eye	185 NX
Liver	103 NX
Pancreas	97 NX
Testis	68 NX
Placenta	52 NX
Lung	50 NX
Skin	39 NX
Heart muscle	26 NX

Enterocytes	87 NX
Rectum	150 NX
Small intestine	96 NX
Colon	64 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	68 NX
Pancreas	68 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	30 NX
Skin	72 NX
Prostate	46 NX
Heart muscle	30 NX
Placenta	18 NX
Lung	8 NX

Glandular cells	84 NX
Prostate	84 NX

Granulocytes	4 NX
Lung	7 NX
Colon	0 NX

Hepatocytes	215 NX
Liver	215 NX

Hofbauer cells	9 NX
Placenta	9 NX

Horizontal cells	37 NX
Eye	37 NX

Intestinal endocrine cells	157 NX
Colon	160 NX
Rectum	155 NX

Ito cells	201 NX
Liver	201 NX

Kupffer cells	48 NX
Liver	48 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	89 NX
Testis	89 NX

Macrophages	27 NX
Prostate	37 NX
Testis	31 NX
Kidney	31 NX
Skin	27 NX
Pancreas	14 NX
Lung	13 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	8 NX
Pancreas	8 NX

Mucus-secreting cells	104 NX
Rectum	126 NX
Small intestine	90 NX
Colon	60 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	68 NX
Pancreas	68 NX

Paneth cells	56 NX
Rectum	76 NX
Small intestine	56 NX
Colon	55 NX

Peritubular cells	231 NX
Testis	231 NX

Proximal tubular cells	116 NX
Kidney	116 NX

Rod photoreceptor cells	22 NX
Eye	22 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	42 NX
Skin	67 NX
Prostate	42 NX
Heart muscle	34 NX
Pancreas	10 NX

Spermatocytes	6 NX
Testis	6 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	60 NX
Skin	60 NX

Syncytiotrophoblasts	32 NX
Placenta	32 NX

T-cells	6 NX
Prostate	18 NX
Skin	10 NX
Kidney	10 NX
Lung	7 NX
Colon	3 NX
Liver	0 NX

Undifferentiated cells	56 NX
Rectum	69 NX
Small intestine	53 NX
Colon	46 NX

Urothelial cells	113 NX
Prostate	113 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.