Cell type atlas - FEZ2 - The Human Protein Atlas

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FEZ2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FEZ2
Gene descriptionⁱ Full gene name according to HGNC.	Fasciculation and elongation protein zeta 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	14 NX
Colon	33 NX
Liver	14 NX
Kidney	13 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	33 NX
Eye	33 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	31 NX
Lung	31 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	56 NX
Kidney	56 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	85 NX
Placenta	85 NX

Distal tubular cells	48 NX
Kidney	48 NX

Ductal cells	58 NX
Pancreas	58 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	79 NX
Testis	157 NX
Placenta	116 NX
Eye	111 NX
Prostate	94 NX
Skin	94 NX
Liver	79 NX
Pancreas	72 NX
Heart muscle	62 NX
Lung	61 NX

Enterocytes	56 NX
Rectum	61 NX
Small intestine	57 NX
Colon	37 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	27 NX
Pancreas	27 NX

Extravillous trophoblasts	75 NX
Placenta	75 NX

Fibroblasts	59 NX
Placenta	64 NX
Skin	61 NX
Lung	48 NX
Prostate	45 NX
Heart muscle	20 NX

Glandular cells	87 NX
Prostate	87 NX

Granulocytes	23 NX
Lung	28 NX
Colon	18 NX

Hepatocytes	32 NX
Liver	32 NX

Hofbauer cells	81 NX
Placenta	81 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	23 NX
Rectum	26 NX
Colon	20 NX

Ito cells	93 NX
Liver	93 NX

Kupffer cells	75 NX
Liver	75 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	50 NX
Testis	50 NX

Macrophages	61 NX
Testis	101 NX
Skin	74 NX
Prostate	65 NX
Lung	65 NX
Kidney	56 NX
Pancreas	44 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	37 NX
Pancreas	37 NX

Mucus-secreting cells	30 NX
Rectum	33 NX
Small intestine	28 NX
Colon	21 NX

Muller glia cells	76 NX
Eye	76 NX

Pancreatic endocrine cells	52 NX
Pancreas	52 NX

Paneth cells	37 NX
Rectum	40 NX
Colon	37 NX
Small intestine	35 NX

Peritubular cells	62 NX
Testis	62 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	52 NX
Pancreas	77 NX
Skin	62 NX
Prostate	52 NX
Heart muscle	18 NX

Spermatocytes	13 NX
Testis	13 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	28 NX
Skin	28 NX

Syncytiotrophoblasts	151 NX
Placenta	151 NX

T-cells	28 NX
Prostate	31 NX
Lung	29 NX
Colon	28 NX
Skin	28 NX
Kidney	27 NX
Liver	22 NX

Undifferentiated cells	33 NX
Rectum	39 NX
Colon	32 NX
Small intestine	31 NX

Urothelial cells	117 NX
Prostate	117 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.