Cell type atlas - NDUFA3 - The Human Protein Atlas

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NDUFA3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA3
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase subunit A3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	115 NX
Lung	115 NX

B-cells	159 NX
Kidney	214 NX
Liver	184 NX
Colon	105 NX

Basal glandular cells	45 NX
Prostate	45 NX

Basal keratinocytes	35 NX
Skin	35 NX

Bipolar cells	35 NX
Eye	35 NX

Cardiomyocytes	1042 NX
Heart muscle	1042 NX

Cholangiocytes	245 NX
Liver	245 NX

Ciliated cells	190 NX
Lung	190 NX

Club cells	114 NX
Lung	114 NX

Collecting duct cells	373 NX
Kidney	373 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	147 NX
Placenta	147 NX

Distal tubular cells	691 NX
Kidney	691 NX

Ductal cells	172 NX
Pancreas	172 NX

Early spermatids	409 NX
Testis	409 NX

Endothelial cells	107 NX
Heart muscle	233 NX
Placenta	184 NX
Liver	182 NX
Testis	117 NX
Pancreas	107 NX
Eye	101 NX
Skin	78 NX
Lung	76 NX
Prostate	27 NX

Enterocytes	555 NX
Small intestine	566 NX
Colon	557 NX
Rectum	421 NX

Erythroid cells	164 NX
Liver	164 NX

Exocrine glandular cells	167 NX
Pancreas	167 NX

Extravillous trophoblasts	150 NX
Placenta	150 NX

Fibroblasts	119 NX
Heart muscle	352 NX
Placenta	142 NX
Lung	124 NX
Skin	68 NX
Prostate	24 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	112 NX
Lung	133 NX
Colon	92 NX

Hepatocytes	460 NX
Liver	460 NX

Hofbauer cells	265 NX
Placenta	265 NX

Horizontal cells	22 NX
Eye	22 NX

Intestinal endocrine cells	289 NX
Rectum	353 NX
Colon	224 NX

Ito cells	206 NX
Liver	206 NX

Kupffer cells	256 NX
Liver	256 NX

Late spermatids	1291 NX
Testis	1291 NX

Leydig cells	151 NX
Testis	151 NX

Macrophages	163 NX
Kidney	433 NX
Pancreas	304 NX
Lung	169 NX
Testis	164 NX
Skin	126 NX
Prostate	48 NX

Melanocytes	208 NX
Skin	208 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	272 NX
Pancreas	272 NX

Mucus-secreting cells	310 NX
Colon	390 NX
Rectum	313 NX
Small intestine	275 NX

Muller glia cells	64 NX
Eye	64 NX

Pancreatic endocrine cells	192 NX
Pancreas	192 NX

Paneth cells	344 NX
Colon	541 NX
Small intestine	344 NX
Rectum	325 NX

Peritubular cells	133 NX
Testis	133 NX

Proximal tubular cells	664 NX
Kidney	664 NX

Rod photoreceptor cells	46 NX
Eye	46 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	82 NX
Heart muscle	355 NX
Pancreas	134 NX
Skin	78 NX
Prostate	35 NX

Spermatocytes	133 NX
Testis	133 NX

Spermatogonia	72 NX
Testis	72 NX

Suprabasal keratinocytes	55 NX
Skin	55 NX

Syncytiotrophoblasts	124 NX
Placenta	124 NX

T-cells	142 NX
Kidney	301 NX
Lung	181 NX
Liver	158 NX
Colon	115 NX
Skin	110 NX
Prostate	57 NX

Undifferentiated cells	318 NX
Rectum	365 NX
Colon	318 NX
Small intestine	268 NX

Urothelial cells	57 NX
Prostate	57 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.