Cell type atlas - NUDCD2 - The Human Protein Atlas

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NUDCD2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUDCD2
Gene descriptionⁱ Full gene name according to HGNC.	NudC domain containing 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	18 NX
Lung	18 NX

B-cells	48 NX
Liver	53 NX
Kidney	49 NX
Colon	48 NX

Basal glandular cells	47 NX
Prostate	47 NX

Basal keratinocytes	53 NX
Skin	53 NX

Bipolar cells	29 NX
Eye	29 NX

Cardiomyocytes	37 NX
Heart muscle	37 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	42 NX
Lung	42 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	97 NX
Placenta	97 NX

Distal tubular cells	126 NX
Kidney	126 NX

Ductal cells	55 NX
Pancreas	55 NX

Early spermatids	61 NX
Testis	61 NX

Endothelial cells	46 NX
Placenta	63 NX
Testis	58 NX
Skin	54 NX
Prostate	50 NX
Heart muscle	49 NX
Liver	36 NX
Pancreas	32 NX
Lung	20 NX
Eye	20 NX

Enterocytes	19 NX
Small intestine	26 NX
Rectum	25 NX
Colon	15 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	56 NX
Pancreas	56 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	50 NX
Placenta	52 NX
Prostate	51 NX
Skin	49 NX
Heart muscle	47 NX
Lung	33 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	30 NX
Lung	42 NX
Colon	18 NX

Hepatocytes	51 NX
Liver	51 NX

Hofbauer cells	61 NX
Placenta	61 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	42 NX
Rectum	47 NX
Colon	37 NX

Ito cells	32 NX
Liver	32 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	48 NX
Testis	48 NX

Macrophages	39 NX
Kidney	52 NX
Pancreas	49 NX
Prostate	45 NX
Testis	39 NX
Skin	37 NX
Lung	26 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	41 NX
Pancreas	41 NX

Mucus-secreting cells	42 NX
Rectum	54 NX
Small intestine	35 NX
Colon	30 NX

Muller glia cells	35 NX
Eye	35 NX

Pancreatic endocrine cells	54 NX
Pancreas	54 NX

Paneth cells	28 NX
Rectum	55 NX
Small intestine	28 NX
Colon	9 NX

Peritubular cells	48 NX
Testis	48 NX

Proximal tubular cells	89 NX
Kidney	89 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	42 NX
Skin	55 NX
Heart muscle	42 NX
Pancreas	41 NX
Prostate	41 NX

Spermatocytes	70 NX
Testis	70 NX

Spermatogonia	43 NX
Testis	43 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	42 NX
Skin	61 NX
Kidney	57 NX
Liver	47 NX
Colon	39 NX
Lung	36 NX
Prostate	35 NX

Undifferentiated cells	61 NX
Small intestine	83 NX
Rectum	61 NX
Colon	49 NX

Urothelial cells	49 NX
Prostate	49 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.