Cell type atlas - PA2G4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PA2G4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PA2G4
Gene descriptionⁱ Full gene name according to HGNC.	Proliferation-associated 2G4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	76 NX
Lung	76 NX

B-cells	104 NX
Liver	230 NX
Kidney	111 NX
Colon	97 NX

Basal glandular cells	177 NX
Prostate	177 NX

Basal keratinocytes	327 NX
Skin	327 NX

Bipolar cells	54 NX
Eye	54 NX

Cardiomyocytes	31 NX
Heart muscle	31 NX

Cholangiocytes	112 NX
Liver	112 NX

Ciliated cells	122 NX
Lung	122 NX

Club cells	171 NX
Lung	171 NX

Collecting duct cells	124 NX
Kidney	124 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	193 NX
Placenta	193 NX

Distal tubular cells	164 NX
Kidney	164 NX

Ductal cells	167 NX
Pancreas	167 NX

Early spermatids	353 NX
Testis	353 NX

Endothelial cells	141 NX
Pancreas	319 NX
Prostate	208 NX
Liver	160 NX
Placenta	152 NX
Testis	141 NX
Skin	140 NX
Lung	108 NX
Eye	74 NX
Heart muscle	17 NX

Enterocytes	88 NX
Small intestine	106 NX
Colon	88 NX
Rectum	55 NX

Erythroid cells	374 NX
Liver	374 NX

Exocrine glandular cells	214 NX
Pancreas	214 NX

Extravillous trophoblasts	240 NX
Placenta	240 NX

Fibroblasts	114 NX
Lung	265 NX
Prostate	171 NX
Placenta	114 NX
Skin	112 NX
Heart muscle	23 NX

Glandular cells	92 NX
Prostate	92 NX

Granulocytes	164 NX
Lung	200 NX
Colon	129 NX

Hepatocytes	167 NX
Liver	167 NX

Hofbauer cells	183 NX
Placenta	183 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	90 NX
Colon	109 NX
Rectum	70 NX

Ito cells	96 NX
Liver	96 NX

Kupffer cells	99 NX
Liver	99 NX

Late spermatids	161 NX
Testis	161 NX

Leydig cells	122 NX
Testis	122 NX

Macrophages	129 NX
Pancreas	199 NX
Testis	141 NX
Kidney	141 NX
Lung	127 NX
Skin	109 NX
Prostate	98 NX

Melanocytes	123 NX
Skin	123 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	116 NX
Pancreas	116 NX

Mucus-secreting cells	123 NX
Colon	212 NX
Rectum	121 NX
Small intestine	83 NX

Muller glia cells	93 NX
Eye	93 NX

Pancreatic endocrine cells	217 NX
Pancreas	217 NX

Paneth cells	95 NX
Rectum	131 NX
Small intestine	95 NX
Colon	49 NX

Peritubular cells	119 NX
Testis	119 NX

Proximal tubular cells	156 NX
Kidney	156 NX

Rod photoreceptor cells	43 NX
Eye	43 NX

Sertoli cells	142 NX
Testis	142 NX

Smooth muscle cells	166 NX
Pancreas	294 NX
Prostate	215 NX
Skin	143 NX
Heart muscle	26 NX

Spermatocytes	162 NX
Testis	162 NX

Spermatogonia	110 NX
Testis	110 NX

Suprabasal keratinocytes	317 NX
Skin	317 NX

Syncytiotrophoblasts	162 NX
Placenta	162 NX

T-cells	164 NX
Kidney	212 NX
Colon	171 NX
Prostate	166 NX
Liver	157 NX
Skin	152 NX
Lung	108 NX

Undifferentiated cells	218 NX
Colon	340 NX
Small intestine	218 NX
Rectum	139 NX

Urothelial cells	202 NX
Prostate	202 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.