Cell type atlas - ELP5 - The Human Protein Atlas

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ELP5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ELP5
Gene descriptionⁱ Full gene name according to HGNC.	Elongator acetyltransferase complex subunit 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	31 NX
Colon	39 NX
Kidney	31 NX
Liver	15 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	21 NX
Eye	21 NX

Cardiomyocytes	59 NX
Heart muscle	59 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	7 NX
Lung	7 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	35 NX
Placenta	35 NX

Distal tubular cells	83 NX
Kidney	83 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	320 NX
Testis	320 NX

Endothelial cells	27 NX
Prostate	49 NX
Placenta	39 NX
Pancreas	32 NX
Skin	29 NX
Testis	28 NX
Liver	27 NX
Lung	20 NX
Heart muscle	17 NX
Eye	11 NX

Enterocytes	27 NX
Small intestine	43 NX
Rectum	33 NX
Colon	14 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	67 NX
Placenta	67 NX

Fibroblasts	24 NX
Prostate	34 NX
Placenta	32 NX
Skin	20 NX
Heart muscle	16 NX
Lung	14 NX

Glandular cells	62 NX
Prostate	62 NX

Granulocytes	7 NX
Colon	9 NX
Lung	5 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	36 NX
Placenta	36 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	40 NX
Rectum	56 NX
Colon	24 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	11 NX
Liver	11 NX

Late spermatids	403 NX
Testis	403 NX

Leydig cells	32 NX
Testis	32 NX

Macrophages	24 NX
Kidney	39 NX
Prostate	37 NX
Skin	27 NX
Pancreas	23 NX
Testis	23 NX
Lung	19 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	27 NX
Pancreas	27 NX

Mucus-secreting cells	34 NX
Rectum	40 NX
Small intestine	32 NX
Colon	28 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	23 NX
Pancreas	23 NX

Paneth cells	35 NX
Rectum	40 NX
Small intestine	35 NX
Colon	14 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	32 NX
Heart muscle	48 NX
Prostate	38 NX
Pancreas	32 NX
Skin	28 NX

Spermatocytes	101 NX
Testis	101 NX

Spermatogonia	37 NX
Testis	37 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	32 NX
Colon	41 NX
Kidney	38 NX
Liver	35 NX
Prostate	26 NX
Skin	25 NX
Lung	14 NX

Undifferentiated cells	48 NX
Rectum	51 NX
Small intestine	45 NX
Colon	35 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.