Cell type atlas - USP47 - The Human Protein Atlas

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USP47

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP47
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 47
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	27 NX
Colon	39 NX
Liver	27 NX
Kidney	9 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	63 NX
Skin	63 NX

Bipolar cells	67 NX
Eye	67 NX

Cardiomyocytes	188 NX
Heart muscle	188 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	67 NX
Lung	67 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	45 NX
Eye	45 NX

Cytotrophoblasts	56 NX
Placenta	56 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	34 NX
Pancreas	34 NX

Early spermatids	26 NX
Testis	26 NX

Endothelial cells	36 NX
Heart muscle	84 NX
Lung	64 NX
Prostate	48 NX
Liver	43 NX
Testis	35 NX
Skin	34 NX
Eye	33 NX
Placenta	26 NX
Pancreas	11 NX

Enterocytes	25 NX
Rectum	33 NX
Small intestine	26 NX
Colon	24 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	34 NX
Pancreas	34 NX

Extravillous trophoblasts	29 NX
Placenta	29 NX

Fibroblasts	48 NX
Heart muscle	141 NX
Prostate	117 NX
Lung	77 NX
Skin	48 NX
Placenta	45 NX

Glandular cells	58 NX
Prostate	58 NX

Granulocytes	51 NX
Lung	84 NX
Colon	18 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	60 NX
Eye	60 NX

Intestinal endocrine cells	57 NX
Colon	65 NX
Rectum	49 NX

Ito cells	30 NX
Liver	30 NX

Kupffer cells	19 NX
Liver	18 NX

Late spermatids	23 NX
Testis	23 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	32 NX
Lung	55 NX
Prostate	36 NX
Skin	32 NX
Testis	27 NX
Kidney	20 NX
Pancreas	19 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	31 NX
Small intestine	34 NX
Rectum	32 NX
Colon	24 NX

Muller glia cells	81 NX
Eye	81 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	32 NX
Rectum	37 NX
Small intestine	32 NX
Colon	17 NX

Peritubular cells	47 NX
Testis	47 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	51 NX
Eye	51 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	47 NX
Heart muscle	166 NX
Prostate	115 NX
Skin	47 NX
Pancreas	33 NX

Spermatocytes	72 NX
Testis	72 NX

Spermatogonia	59 NX
Testis	59 NX

Suprabasal keratinocytes	77 NX
Skin	77 NX

Syncytiotrophoblasts	105 NX
Placenta	105 NX

T-cells	47 NX
Prostate	70 NX
Colon	61 NX
Kidney	51 NX
Lung	50 NX
Skin	45 NX
Liver	38 NX

Undifferentiated cells	32 NX
Rectum	34 NX
Colon	32 NX
Small intestine	29 NX

Urothelial cells	48 NX
Prostate	48 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.