Cell type atlas - BRD3 - The Human Protein Atlas

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BRD3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BRD3
Gene descriptionⁱ Full gene name according to HGNC.	Bromodomain containing 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	14 NX
Liver	16 NX
Colon	15 NX
Kidney	13 NX

Basal glandular cells	18 NX
Prostate	18 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	54 NX
Eye	54 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	30 NX
Lung	30 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	22 NX
Placenta	22 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	37 NX
Pancreas	37 NX

Early spermatids	34 NX
Testis	34 NX

Endothelial cells	27 NX
Lung	38 NX
Eye	37 NX
Skin	36 NX
Placenta	29 NX
Liver	29 NX
Testis	27 NX
Prostate	23 NX
Pancreas	18 NX
Heart muscle	16 NX

Enterocytes	15 NX
Rectum	26 NX
Small intestine	16 NX
Colon	14 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	30 NX
Skin	31 NX
Placenta	31 NX
Prostate	31 NX
Lung	24 NX
Heart muscle	16 NX

Glandular cells	33 NX
Prostate	33 NX

Granulocytes	16 NX
Colon	28 NX
Lung	5 NX

Hepatocytes	25 NX
Liver	25 NX

Hofbauer cells	16 NX
Placenta	16 NX

Horizontal cells	54 NX
Eye	54 NX

Intestinal endocrine cells	52 NX
Rectum	56 NX
Colon	48 NX

Ito cells	27 NX
Liver	27 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	21 NX
Testis	37 NX
Prostate	21 NX
Skin	21 NX
Kidney	20 NX
Lung	18 NX
Pancreas	5 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	19 NX
Pancreas	19 NX

Mucus-secreting cells	25 NX
Rectum	29 NX
Small intestine	20 NX
Colon	20 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	25 NX
Pancreas	25 NX

Paneth cells	21 NX
Rectum	29 NX
Small intestine	21 NX
Colon	9 NX

Peritubular cells	63 NX
Testis	63 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	54 NX
Eye	54 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	33 NX
Skin	48 NX
Heart muscle	33 NX
Prostate	32 NX
Pancreas	17 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	61 NX
Testis	61 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	27 NX
Placenta	27 NX

T-cells	26 NX
Liver	38 NX
Colon	28 NX
Skin	26 NX
Lung	23 NX
Kidney	19 NX
Prostate	9 NX

Undifferentiated cells	30 NX
Small intestine	33 NX
Rectum	32 NX
Colon	15 NX

Urothelial cells	15 NX
Prostate	15 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.