Cell type atlas - GUSB - The Human Protein Atlas

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GUSB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GUSB
Gene descriptionⁱ Full gene name according to HGNC.	Glucuronidase beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	56 NX
Lung	56 NX

B-cells	19 NX
Liver	38 NX
Kidney	22 NX
Colon	15 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	16 NX
Skin	16 NX

Bipolar cells	14 NX
Eye	14 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	72 NX
Placenta	72 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	48 NX
Testis	48 NX

Endothelial cells	31 NX
Lung	85 NX
Placenta	60 NX
Skin	42 NX
Liver	32 NX
Testis	32 NX
Eye	23 NX
Prostate	21 NX
Heart muscle	20 NX
Pancreas	11 NX

Enterocytes	41 NX
Rectum	57 NX
Small intestine	43 NX
Colon	31 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	27 NX
Pancreas	27 NX

Extravillous trophoblasts	49 NX
Placenta	49 NX

Fibroblasts	48 NX
Skin	56 NX
Placenta	54 NX
Prostate	28 NX
Lung	22 NX
Heart muscle	18 NX

Glandular cells	26 NX
Prostate	25 NX

Granulocytes	36 NX
Colon	37 NX
Lung	35 NX

Hepatocytes	65 NX
Liver	65 NX

Hofbauer cells	114 NX
Placenta	114 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	41 NX
Colon	54 NX
Rectum	28 NX

Ito cells	40 NX
Liver	40 NX

Kupffer cells	74 NX
Liver	74 NX

Late spermatids	37 NX
Testis	37 NX

Leydig cells	40 NX
Testis	40 NX

Macrophages	72 NX
Lung	124 NX
Pancreas	105 NX
Prostate	81 NX
Kidney	63 NX
Testis	46 NX
Skin	33 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	43 NX
Pancreas	43 NX

Mucus-secreting cells	42 NX
Colon	51 NX
Rectum	44 NX
Small intestine	36 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	49 NX
Rectum	63 NX
Colon	49 NX
Small intestine	21 NX

Peritubular cells	27 NX
Testis	27 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	18 NX
Eye	18 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	23 NX
Skin	28 NX
Pancreas	25 NX
Prostate	20 NX
Heart muscle	15 NX

Spermatocytes	41 NX
Testis	41 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	13 NX
Skin	13 NX

Syncytiotrophoblasts	56 NX
Placenta	56 NX

T-cells	35 NX
Lung	65 NX
Liver	46 NX
Kidney	41 NX
Colon	28 NX
Skin	24 NX
Prostate	9 NX

Undifferentiated cells	41 NX
Rectum	52 NX
Small intestine	39 NX
Colon	28 NX

Urothelial cells	25 NX
Prostate	25 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.