Cell type atlas - DCXR - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DCXR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCXR
Gene descriptionⁱ Full gene name according to HGNC.	Dicarbonyl and L-xylulose reductase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Hepatocytes, Proximal tubular cells, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Hep G2, MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Hepatocytes, Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	156 NX
Lung	156 NX

B-cells	118 NX
Kidney	143 NX
Liver	118 NX
Colon	97 NX

Basal glandular cells	185 NX
Prostate	185 NX

Basal keratinocytes	52 NX
Skin	52 NX

Bipolar cells	16 NX
Eye	16 NX

Cardiomyocytes	102 NX
Heart muscle	102 NX

Cholangiocytes	125 NX
Liver	125 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	169 NX
Kidney	169 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	343 NX
Placenta	343 NX

Distal tubular cells	688 NX
Kidney	688 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	35 NX
Placenta	62 NX
Prostate	55 NX
Liver	52 NX
Heart muscle	42 NX
Skin	40 NX
Eye	29 NX
Testis	24 NX
Pancreas	22 NX
Lung	20 NX

Enterocytes	136 NX
Colon	190 NX
Small intestine	124 NX
Rectum	102 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	377 NX
Placenta	377 NX

Fibroblasts	68 NX
Placenta	96 NX
Heart muscle	77 NX
Prostate	68 NX
Skin	52 NX
Lung	32 NX

Glandular cells	204 NX
Prostate	203 NX

Granulocytes	65 NX
Colon	92 NX
Lung	37 NX

Hepatocytes	2593 NX
Liver	2593 NX

Hofbauer cells	145 NX
Placenta	145 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	53 NX
Rectum	68 NX
Colon	37 NX

Ito cells	88 NX
Liver	88 NX

Kupffer cells	115 NX
Liver	115 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	66 NX
Testis	66 NX

Macrophages	57 NX
Kidney	275 NX
Prostate	127 NX
Pancreas	89 NX
Skin	57 NX
Lung	49 NX
Testis	33 NX

Melanocytes	170 NX
Skin	170 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	48 NX
Pancreas	48 NX

Mucus-secreting cells	117 NX
Colon	232 NX
Rectum	108 NX
Small intestine	108 NX

Muller glia cells	82 NX
Eye	82 NX

Pancreatic endocrine cells	32 NX
Pancreas	32 NX

Paneth cells	105 NX
Colon	176 NX
Rectum	105 NX
Small intestine	84 NX

Peritubular cells	45 NX
Testis	45 NX

Proximal tubular cells	1818 NX
Kidney	1818 NX

Rod photoreceptor cells	19 NX
Eye	19 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	67 NX
Prostate	73 NX
Skin	72 NX
Pancreas	55 NX
Heart muscle	46 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	64 NX
Skin	64 NX

Syncytiotrophoblasts	287 NX
Placenta	287 NX

T-cells	127 NX
Skin	185 NX
Kidney	184 NX
Prostate	140 NX
Colon	139 NX
Liver	120 NX
Lung	73 NX

Undifferentiated cells	129 NX
Colon	187 NX
Rectum	129 NX
Small intestine	98 NX

Urothelial cells	156 NX
Prostate	156 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.