Cell type atlas - LMAN2 - The Human Protein Atlas

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LMAN2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LMAN2
Gene descriptionⁱ Full gene name according to HGNC.	Lectin, mannose binding 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	75 NX
Lung	75 NX

B-cells	76 NX
Liver	211 NX
Kidney	80 NX
Colon	72 NX

Basal glandular cells	123 NX
Prostate	123 NX

Basal keratinocytes	51 NX
Skin	51 NX

Bipolar cells	29 NX
Eye	29 NX

Cardiomyocytes	41 NX
Heart muscle	41 NX

Cholangiocytes	133 NX
Liver	133 NX

Ciliated cells	82 NX
Lung	82 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	103 NX
Kidney	103 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	270 NX
Placenta	270 NX

Distal tubular cells	45 NX
Kidney	45 NX

Ductal cells	202 NX
Pancreas	202 NX

Early spermatids	69 NX
Testis	69 NX

Endothelial cells	77 NX
Placenta	181 NX
Pancreas	165 NX
Prostate	100 NX
Eye	93 NX
Testis	77 NX
Skin	73 NX
Heart muscle	71 NX
Liver	61 NX
Lung	58 NX

Enterocytes	153 NX
Small intestine	161 NX
Rectum	142 NX
Colon	140 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	208 NX
Pancreas	208 NX

Extravillous trophoblasts	337 NX
Placenta	337 NX

Fibroblasts	120 NX
Placenta	218 NX
Prostate	127 NX
Heart muscle	110 NX
Skin	79 NX
Lung	60 NX

Glandular cells	135 NX
Prostate	135 NX

Granulocytes	77 NX
Colon	110 NX
Lung	44 NX

Hepatocytes	199 NX
Liver	199 NX

Hofbauer cells	216 NX
Placenta	216 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	57 NX
Rectum	73 NX
Colon	41 NX

Ito cells	72 NX
Liver	72 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	17 NX
Testis	17 NX

Leydig cells	81 NX
Testis	81 NX

Macrophages	90 NX
Pancreas	227 NX
Prostate	166 NX
Kidney	141 NX
Skin	83 NX
Testis	78 NX
Lung	74 NX

Melanocytes	115 NX
Skin	115 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	127 NX
Pancreas	127 NX

Mucus-secreting cells	115 NX
Colon	261 NX
Small intestine	115 NX
Rectum	112 NX

Muller glia cells	87 NX
Eye	87 NX

Pancreatic endocrine cells	202 NX
Pancreas	202 NX

Paneth cells	122 NX
Colon	127 NX
Rectum	122 NX
Small intestine	105 NX

Peritubular cells	60 NX
Testis	60 NX

Proximal tubular cells	92 NX
Kidney	92 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	82 NX
Pancreas	206 NX
Heart muscle	82 NX
Prostate	82 NX
Skin	49 NX

Spermatocytes	262 NX
Testis	262 NX

Spermatogonia	200 NX
Testis	200 NX

Suprabasal keratinocytes	61 NX
Skin	61 NX

Syncytiotrophoblasts	444 NX
Placenta	444 NX

T-cells	122 NX
Prostate	174 NX
Kidney	160 NX
Colon	122 NX
Liver	120 NX
Skin	111 NX
Lung	94 NX

Undifferentiated cells	130 NX
Colon	198 NX
Small intestine	130 NX
Rectum	122 NX

Urothelial cells	137 NX
Prostate	137 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.