Cell type atlas - SLC25A6 - The Human Protein Atlas

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SLC25A6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A6
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	137 NX
Lung	137 NX

Alveolar cells type 2	195 NX
Lung	195 NX

B-cells	872 NX
Liver	924 NX
Kidney	833 NX
Colon	684 NX

Basal glandular cells	1042 NX
Prostate	1042 NX

Basal keratinocytes	1023 NX
Skin	1023 NX

Bipolar cells	283 NX
Eye	283 NX

Cardiomyocytes	87 NX
Heart muscle	87 NX

Cholangiocytes	257 NX
Liver	257 NX

Ciliated cells	129 NX
Lung	129 NX

Club cells	281 NX
Lung	281 NX

Collecting duct cells	300 NX
Kidney	300 NX

Cone photoreceptor cells	92 NX
Eye	92 NX

Cytotrophoblasts	1322 NX
Placenta	1322 NX

Distal tubular cells	1406 NX
Kidney	1406 NX

Ductal cells	633 NX
Pancreas	633 NX

Early spermatids	9 NX
Testis	9 NX

Endothelial cells	418 NX
Skin	1006 NX
Prostate	902 NX
Placenta	735 NX
Testis	455 NX
Liver	418 NX
Pancreas	322 NX
Lung	260 NX
Eye	237 NX
Heart muscle	99 NX

Enterocytes	863 NX
Small intestine	1314 NX
Colon	836 NX
Rectum	492 NX

Erythroid cells	304 NX
Liver	304 NX

Exocrine glandular cells	1275 NX
Pancreas	1275 NX

Extravillous trophoblasts	964 NX
Placenta	964 NX

Fibroblasts	807 NX
Placenta	882 NX
Skin	793 NX
Prostate	777 NX
Lung	457 NX
Heart muscle	111 NX

Glandular cells	856 NX
Prostate	856 NX

Granulocytes	337 NX
Colon	386 NX
Lung	288 NX

Hepatocytes	133 NX
Liver	133 NX

Hofbauer cells	1091 NX
Placenta	1090 NX

Horizontal cells	229 NX
Eye	229 NX

Intestinal endocrine cells	892 NX
Rectum	992 NX
Colon	792 NX

Ito cells	412 NX
Liver	412 NX

Kupffer cells	1235 NX
Liver	1235 NX

Late spermatids	27 NX
Testis	26 NX

Leydig cells	618 NX
Testis	618 NX

Macrophages	976 NX
Prostate	1766 NX
Kidney	1169 NX
Testis	1071 NX
Skin	1043 NX
Pancreas	639 NX
Lung	366 NX

Melanocytes	715 NX
Skin	715 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1354 NX
Pancreas	1354 NX

Mucus-secreting cells	1107 NX
Rectum	1421 NX
Colon	1079 NX
Small intestine	770 NX

Muller glia cells	101 NX
Eye	101 NX

Pancreatic endocrine cells	835 NX
Pancreas	835 NX

Paneth cells	867 NX
Rectum	1333 NX
Colon	867 NX
Small intestine	859 NX

Peritubular cells	344 NX
Testis	344 NX

Proximal tubular cells	1021 NX
Kidney	1021 NX

Rod photoreceptor cells	200 NX
Eye	200 NX

Sertoli cells	336 NX
Testis	336 NX

Smooth muscle cells	860 NX
Prostate	1327 NX
Skin	1004 NX
Pancreas	860 NX
Heart muscle	149 NX

Spermatocytes	13 NX
Testis	13 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	1155 NX
Skin	1155 NX

Syncytiotrophoblasts	1459 NX
Placenta	1459 NX

T-cells	554 NX
Skin	790 NX
Kidney	748 NX
Liver	606 NX
Prostate	554 NX
Colon	547 NX
Lung	283 NX

Undifferentiated cells	1380 NX
Rectum	1562 NX
Small intestine	1490 NX
Colon	825 NX

Urothelial cells	1329 NX
Prostate	1329 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.