Cell type atlas - MAP2K1 - The Human Protein Atlas

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MAP2K1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAP2K1
Gene descriptionⁱ Full gene name according to HGNC.	Mitogen-activated protein kinase kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes FDA approved drug targets RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	22 NX
Lung	22 NX

B-cells	30 NX
Kidney	40 NX
Colon	21 NX
Liver	20 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	74 NX
Skin	74 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	7 NX
Lung	7 NX

Club cells	14 NX
Lung	14 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	40 NX
Kidney	40 NX

Ductal cells	65 NX
Pancreas	65 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	19 NX
Pancreas	118 NX
Prostate	67 NX
Skin	43 NX
Liver	36 NX
Heart muscle	19 NX
Placenta	16 NX
Testis	15 NX
Eye	13 NX
Lung	12 NX

Enterocytes	20 NX
Rectum	25 NX
Colon	20 NX
Small intestine	19 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	20 NX
Pancreas	20 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	31 NX
Prostate	98 NX
Skin	54 NX
Placenta	20 NX
Lung	13 NX
Heart muscle	13 NX

Glandular cells	59 NX
Prostate	59 NX

Granulocytes	9 NX
Colon	18 NX
Lung	0 NX

Hepatocytes	117 NX
Liver	117 NX

Hofbauer cells	45 NX
Placenta	45 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	21 NX
Rectum	28 NX
Colon	14 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	91 NX
Liver	91 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	68 NX
Prostate	173 NX
Skin	165 NX
Testis	153 NX
Kidney	64 NX
Lung	53 NX
Pancreas	52 NX

Melanocytes	51 NX
Skin	51 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	88 NX
Pancreas	88 NX

Mucus-secreting cells	17 NX
Rectum	20 NX
Small intestine	14 NX
Colon	7 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	70 NX
Pancreas	70 NX

Paneth cells	21 NX
Rectum	22 NX
Small intestine	21 NX
Colon	20 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	6 NX
Eye	6 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	54 NX
Skin	67 NX
Pancreas	65 NX
Prostate	47 NX
Heart muscle	34 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	43 NX
Placenta	43 NX

T-cells	41 NX
Skin	94 NX
Prostate	57 NX
Kidney	56 NX
Colon	43 NX
Liver	35 NX
Lung	14 NX

Undifferentiated cells	17 NX
Rectum	22 NX
Small intestine	16 NX
Colon	16 NX

Urothelial cells	66 NX
Prostate	66 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.