Cell type atlas - UQCRFS1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

UQCRFS1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRFS1
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	83 NX
Liver	147 NX
Colon	105 NX
Kidney	62 NX

Basal glandular cells	229 NX
Prostate	229 NX

Basal keratinocytes	131 NX
Skin	131 NX

Bipolar cells	67 NX
Eye	67 NX

Cardiomyocytes	1206 NX
Heart muscle	1206 NX

Cholangiocytes	171 NX
Liver	171 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	108 NX
Kidney	108 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	255 NX
Placenta	255 NX

Distal tubular cells	877 NX
Kidney	877 NX

Ductal cells	208 NX
Pancreas	208 NX

Early spermatids	177 NX
Testis	177 NX

Endothelial cells	94 NX
Heart muscle	224 NX
Prostate	152 NX
Placenta	146 NX
Pancreas	143 NX
Liver	94 NX
Testis	80 NX
Skin	73 NX
Eye	68 NX
Lung	47 NX

Enterocytes	303 NX
Rectum	338 NX
Small intestine	305 NX
Colon	232 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	205 NX
Pancreas	205 NX

Extravillous trophoblasts	204 NX
Placenta	204 NX

Fibroblasts	122 NX
Heart muscle	345 NX
Prostate	159 NX
Placenta	147 NX
Skin	72 NX
Lung	69 NX

Glandular cells	163 NX
Prostate	163 NX

Granulocytes	89 NX
Colon	101 NX
Lung	77 NX

Hepatocytes	250 NX
Liver	250 NX

Hofbauer cells	234 NX
Placenta	234 NX

Horizontal cells	49 NX
Eye	49 NX

Intestinal endocrine cells	154 NX
Rectum	155 NX
Colon	153 NX

Ito cells	94 NX
Liver	94 NX

Kupffer cells	136 NX
Liver	136 NX

Late spermatids	103 NX
Testis	103 NX

Leydig cells	85 NX
Testis	85 NX

Macrophages	113 NX
Kidney	221 NX
Pancreas	211 NX
Prostate	181 NX
Testis	125 NX
Skin	95 NX
Lung	86 NX

Melanocytes	157 NX
Skin	157 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	179 NX
Pancreas	179 NX

Mucus-secreting cells	238 NX
Colon	349 NX
Rectum	271 NX
Small intestine	160 NX

Muller glia cells	97 NX
Eye	97 NX

Pancreatic endocrine cells	186 NX
Pancreas	186 NX

Paneth cells	196 NX
Rectum	265 NX
Small intestine	196 NX
Colon	153 NX

Peritubular cells	77 NX
Testis	77 NX

Proximal tubular cells	532 NX
Kidney	532 NX

Rod photoreceptor cells	59 NX
Eye	59 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	164 NX
Heart muscle	215 NX
Pancreas	209 NX
Prostate	164 NX
Skin	69 NX

Spermatocytes	297 NX
Testis	297 NX

Spermatogonia	77 NX
Testis	77 NX

Suprabasal keratinocytes	140 NX
Skin	140 NX

Syncytiotrophoblasts	319 NX
Placenta	319 NX

T-cells	108 NX
Kidney	147 NX
Colon	133 NX
Prostate	109 NX
Skin	108 NX
Liver	97 NX
Lung	83 NX

Undifferentiated cells	325 NX
Colon	376 NX
Rectum	372 NX
Small intestine	293 NX

Urothelial cells	308 NX
Prostate	308 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.