Cell type atlas - MAT2A - The Human Protein Atlas

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MAT2A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAT2A
Gene descriptionⁱ Full gene name according to HGNC.	Methionine adenosyltransferase 2A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	76 NX
Lung	76 NX

B-cells	37 NX
Colon	102 NX
Liver	35 NX
Kidney	18 NX

Basal glandular cells	172 NX
Prostate	172 NX

Basal keratinocytes	128 NX
Skin	128 NX

Bipolar cells	82 NX
Eye	82 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	87 NX
Liver	87 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	50 NX
Pancreas	50 NX

Early spermatids	46 NX
Testis	46 NX

Endothelial cells	49 NX
Skin	138 NX
Eye	113 NX
Prostate	105 NX
Liver	56 NX
Testis	49 NX
Lung	44 NX
Placenta	29 NX
Pancreas	22 NX
Heart muscle	6 NX

Enterocytes	61 NX
Colon	75 NX
Small intestine	63 NX
Rectum	42 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	50 NX
Pancreas	50 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	64 NX
Prostate	196 NX
Skin	118 NX
Lung	95 NX
Placenta	45 NX
Heart muscle	7 NX

Glandular cells	55 NX
Prostate	55 NX

Granulocytes	83 NX
Colon	101 NX
Lung	65 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	58 NX
Placenta	58 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	80 NX
Colon	122 NX
Rectum	37 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	107 NX
Liver	107 NX

Late spermatids	21 NX
Testis	21 NX

Leydig cells	67 NX
Testis	67 NX

Macrophages	93 NX
Testis	137 NX
Skin	109 NX
Kidney	101 NX
Lung	79 NX
Prostate	77 NX
Pancreas	33 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	35 NX
Pancreas	35 NX

Mucus-secreting cells	56 NX
Colon	67 NX
Small intestine	56 NX
Rectum	47 NX

Muller glia cells	60 NX
Eye	60 NX

Pancreatic endocrine cells	56 NX
Pancreas	55 NX

Paneth cells	42 NX
Rectum	54 NX
Small intestine	42 NX
Colon	35 NX

Peritubular cells	79 NX
Testis	79 NX

Proximal tubular cells	120 NX
Kidney	120 NX

Rod photoreceptor cells	81 NX
Eye	81 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	102 NX
Prostate	401 NX
Skin	341 NX
Pancreas	46 NX
Heart muscle	21 NX

Spermatocytes	51 NX
Testis	51 NX

Spermatogonia	58 NX
Testis	58 NX

Suprabasal keratinocytes	103 NX
Skin	103 NX

Syncytiotrophoblasts	32 NX
Placenta	32 NX

T-cells	36 NX
Colon	86 NX
Prostate	65 NX
Skin	48 NX
Kidney	34 NX
Lung	32 NX
Liver	27 NX

Undifferentiated cells	52 NX
Colon	62 NX
Rectum	52 NX
Small intestine	51 NX

Urothelial cells	87 NX
Prostate	87 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.