Cell type atlas - STAT3 - The Human Protein Atlas

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STAT3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAT3
Gene descriptionⁱ Full gene name according to HGNC.	Signal transducer and activator of transcription 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	86 NX
Lung	86 NX

Alveolar cells type 2	151 NX
Lung	151 NX

B-cells	56 NX
Colon	140 NX
Kidney	62 NX
Liver	39 NX

Basal glandular cells	91 NX
Prostate	91 NX

Basal keratinocytes	115 NX
Skin	115 NX

Bipolar cells	87 NX
Eye	87 NX

Cardiomyocytes	46 NX
Heart muscle	46 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	86 NX
Lung	86 NX

Club cells	108 NX
Lung	108 NX

Collecting duct cells	127 NX
Kidney	127 NX

Cone photoreceptor cells	265 NX
Eye	265 NX

Cytotrophoblasts	21 NX
Placenta	21 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	69 NX
Pancreas	69 NX

Early spermatids	27 NX
Testis	27 NX

Endothelial cells	108 NX
Eye	255 NX
Prostate	223 NX
Skin	210 NX
Lung	114 NX
Testis	108 NX
Placenta	107 NX
Heart muscle	85 NX
Pancreas	82 NX
Liver	76 NX

Enterocytes	156 NX
Colon	204 NX
Small intestine	186 NX
Rectum	67 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	84 NX
Pancreas	84 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	141 NX
Prostate	207 NX
Skin	190 NX
Lung	141 NX
Placenta	69 NX
Heart muscle	63 NX

Glandular cells	148 NX
Prostate	148 NX

Granulocytes	139 NX
Colon	147 NX
Lung	130 NX

Hepatocytes	103 NX
Liver	103 NX

Hofbauer cells	60 NX
Placenta	60 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	119 NX
Rectum	119 NX
Colon	119 NX

Ito cells	104 NX
Liver	104 NX

Kupffer cells	65 NX
Liver	65 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	66 NX
Testis	66 NX

Macrophages	85 NX
Prostate	117 NX
Lung	95 NX
Kidney	89 NX
Skin	87 NX
Testis	76 NX
Pancreas	44 NX

Melanocytes	69 NX
Skin	69 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	88 NX
Pancreas	88 NX

Mucus-secreting cells	68 NX
Colon	112 NX
Small intestine	89 NX
Rectum	63 NX

Muller glia cells	108 NX
Eye	108 NX

Pancreatic endocrine cells	76 NX
Pancreas	76 NX

Paneth cells	95 NX
Colon	104 NX
Small intestine	95 NX
Rectum	58 NX

Peritubular cells	57 NX
Testis	57 NX

Proximal tubular cells	38 NX
Kidney	38 NX

Rod photoreceptor cells	352 NX
Eye	352 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	221 NX
Prostate	253 NX
Skin	241 NX
Heart muscle	76 NX
Pancreas	36 NX

Spermatocytes	32 NX
Testis	32 NX

Spermatogonia	15 NX
Testis	15 NX

Suprabasal keratinocytes	140 NX
Skin	140 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	86 NX
Colon	210 NX
Prostate	170 NX
Skin	141 NX
Kidney	126 NX
Lung	86 NX
Liver	32 NX

Undifferentiated cells	73 NX
Colon	114 NX
Small intestine	83 NX
Rectum	68 NX

Urothelial cells	79 NX
Prostate	79 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.