Cell type atlas - COL3A1 - The Human Protein Atlas

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COL3A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COL3A1
Gene descriptionⁱ Full gene name according to HGNC.	Collagen type III alpha 1 chain
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Fibroblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (AF22, ASC diff, ASC TERT1, fHDF/TERT166, HHSteC, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Fibroblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	3 NX
Lung	3 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	0 NX
Liver	1 NX
Kidney	0 NX
Colon	0 NX

Basal glandular cells	0 NX
Prostate	0 NX

Basal keratinocytes	152 NX
Skin	152 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	0 NX
Liver	0 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	2 NX
Lung	2 NX

Collecting duct cells	0 NX
Kidney	0 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	40 NX
Placenta	40 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	3 NX
Pancreas	2 NX

Early spermatids	22 NX
Testis	22 NX

Endothelial cells	53 NX
Skin	167 NX
Placenta	149 NX
Liver	70 NX
Lung	53 NX
Testis	53 NX
Heart muscle	35 NX
Prostate	14 NX
Eye	8 NX
Pancreas	0 NX

Enterocytes	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	0 NX
Pancreas	0 NX

Extravillous trophoblasts	35 NX
Placenta	35 NX

Fibroblasts	1856 NX
Placenta	4755 NX
Skin	3159 NX
Lung	379 NX
Heart muscle	237 NX
Prostate	80 NX

Glandular cells	1 NX
Prostate	1 NX

Granulocytes	6 NX
Lung	12 NX
Colon	0 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	82 NX
Placenta	82 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	6 NX
Colon	7 NX
Rectum	5 NX

Ito cells	359 NX
Liver	359 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	299 NX
Testis	299 NX

Macrophages	4 NX
Skin	186 NX
Lung	8 NX
Testis	4 NX
Pancreas	2 NX
Prostate	2 NX
Kidney	0 NX

Melanocytes	164 NX
Skin	164 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	6 NX
Pancreas	6 NX

Paneth cells	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Peritubular cells	222 NX
Testis	222 NX

Proximal tubular cells	0 NX
Kidney	0 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	446 NX
Testis	446 NX

Smooth muscle cells	215 NX
Pancreas	1918 NX
Skin	417 NX
Heart muscle	215 NX
Prostate	107 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	136 NX
Skin	136 NX

Syncytiotrophoblasts	106 NX
Placenta	106 NX

T-cells	0 NX
Skin	200 NX
Lung	9 NX
Prostate	0 NX
Liver	0 NX
Kidney	0 NX
Colon	0 NX

Undifferentiated cells	0 NX
Rectum	0 NX
Small intestine	0 NX
Colon	0 NX

Urothelial cells	0 NX
Prostate	0 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.