Cell type atlas - SEPT2 - The Human Protein Atlas

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SEPT2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SEPT2
Gene descriptionⁱ Full gene name according to HGNC.	Septin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	23

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	143 NX
Lung	143 NX

Alveolar cells type 2	106 NX
Lung	106 NX

B-cells	91 NX
Liver	95 NX
Colon	93 NX
Kidney	89 NX

Basal glandular cells	0 NX
Prostate	0 NX

Basal keratinocytes	77 NX
Skin	77 NX

Bipolar cells	52 NX
Eye	52 NX

Cardiomyocytes	115 NX
Heart muscle	115 NX

Cholangiocytes	71 NX
Liver	71 NX

Ciliated cells	118 NX
Lung	118 NX

Club cells	135 NX
Lung	135 NX

Collecting duct cells	89 NX
Kidney	89 NX

Cone photoreceptor cells	71 NX
Eye	71 NX

Cytotrophoblasts	119 NX
Placenta	119 NX

Distal tubular cells	114 NX
Kidney	114 NX

Ductal cells	0 NX
Pancreas	0 NX

Early spermatids	158 NX
Testis	158 NX

Endothelial cells	127 NX
Lung	198 NX
Heart muscle	171 NX
Placenta	169 NX
Testis	155 NX
Liver	135 NX
Eye	122 NX
Skin	115 NX
Pancreas	0 NX
Prostate	0 NX

Enterocytes	52 NX
Rectum	72 NX
Colon	52 NX
Small intestine	47 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	0 NX
Pancreas	0 NX

Extravillous trophoblasts	159 NX
Placenta	159 NX

Fibroblasts	147 NX
Lung	160 NX
Placenta	151 NX
Heart muscle	147 NX
Skin	133 NX
Prostate	0 NX

Glandular cells	0 NX
Prostate	0 NX

Granulocytes	333 NX
Lung	400 NX
Colon	266 NX

Hepatocytes	52 NX
Liver	52 NX

Hofbauer cells	119 NX
Placenta	119 NX

Horizontal cells	54 NX
Eye	54 NX

Intestinal endocrine cells	86 NX
Rectum	87 NX
Colon	85 NX

Ito cells	135 NX
Liver	135 NX

Kupffer cells	101 NX
Liver	101 NX

Late spermatids	141 NX
Testis	141 NX

Leydig cells	122 NX
Testis	122 NX

Macrophages	111 NX
Lung	143 NX
Skin	122 NX
Testis	110 NX
Kidney	91 NX
Pancreas	0 NX
Prostate	0 NX

Melanocytes	83 NX
Skin	83 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	0 NX
Pancreas	0 NX

Mucus-secreting cells	73 NX
Colon	76 NX
Rectum	70 NX
Small intestine	65 NX

Muller glia cells	155 NX
Eye	155 NX

Pancreatic endocrine cells	0 NX
Pancreas	0 NX

Paneth cells	80 NX
Small intestine	102 NX
Rectum	80 NX
Colon	40 NX

Peritubular cells	175 NX
Testis	175 NX

Proximal tubular cells	96 NX
Kidney	96 NX

Rod photoreceptor cells	58 NX
Eye	58 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	144 NX
Heart muscle	232 NX
Skin	152 NX
Prostate	0 NX
Pancreas	0 NX

Spermatocytes	132 NX
Testis	132 NX

Spermatogonia	84 NX
Testis	84 NX

Suprabasal keratinocytes	81 NX
Skin	81 NX

Syncytiotrophoblasts	116 NX
Placenta	116 NX

T-cells	83 NX
Lung	119 NX
Colon	107 NX
Kidney	85 NX
Skin	83 NX
Liver	65 NX
Prostate	0 NX

Undifferentiated cells	88 NX
Colon	94 NX
Rectum	87 NX
Small intestine	84 NX

Urothelial cells	0 NX
Prostate	0 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.