Cell type atlas - IRF2 - The Human Protein Atlas

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IRF2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IRF2
Gene descriptionⁱ Full gene name according to HGNC.	Interferon regulatory factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	52 NX
Kidney	76 NX
Liver	47 NX
Colon	37 NX

Basal glandular cells	43 NX
Prostate	43 NX

Basal keratinocytes	44 NX
Skin	44 NX

Bipolar cells	12 NX
Eye	12 NX

Cardiomyocytes	20 NX
Heart muscle	20 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	64 NX
Lung	64 NX

Club cells	26 NX
Lung	26 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	36 NX
Prostate	58 NX
Skin	57 NX
Testis	52 NX
Eye	44 NX
Placenta	36 NX
Liver	36 NX
Lung	32 NX
Heart muscle	25 NX
Pancreas	11 NX

Enterocytes	33 NX
Rectum	47 NX
Small intestine	35 NX
Colon	19 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	30 NX
Skin	38 NX
Lung	38 NX
Prostate	38 NX
Placenta	25 NX
Heart muscle	25 NX

Glandular cells	57 NX
Prostate	57 NX

Granulocytes	27 NX
Colon	37 NX
Lung	16 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	43 NX
Placenta	43 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	29 NX
Rectum	35 NX
Colon	24 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	74 NX
Liver	74 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	48 NX
Kidney	94 NX
Testis	76 NX
Skin	54 NX
Lung	44 NX
Pancreas	37 NX
Prostate	27 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	173 NX
Pancreas	173 NX

Mucus-secreting cells	26 NX
Rectum	30 NX
Colon	26 NX
Small intestine	23 NX

Muller glia cells	26 NX
Eye	26 NX

Pancreatic endocrine cells	27 NX
Pancreas	27 NX

Paneth cells	37 NX
Small intestine	39 NX
Colon	37 NX
Rectum	30 NX

Peritubular cells	50 NX
Testis	50 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	8 NX
Eye	8 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	25 NX
Skin	55 NX
Prostate	25 NX
Pancreas	13 NX
Heart muscle	12 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	39 NX
Skin	39 NX

Syncytiotrophoblasts	22 NX
Placenta	22 NX

T-cells	59 NX
Kidney	68 NX
Liver	62 NX
Lung	59 NX
Colon	57 NX
Skin	35 NX
Prostate	18 NX

Undifferentiated cells	21 NX
Rectum	23 NX
Small intestine	20 NX
Colon	14 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.