Cell type atlas - RBPJ - The Human Protein Atlas

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RBPJ

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RBPJ
Gene descriptionⁱ Full gene name according to HGNC.	Recombination signal binding protein for immunoglobulin kappa J region
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	22

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	63 NX
Lung	63 NX

B-cells	40 NX
Colon	61 NX
Kidney	45 NX
Liver	32 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	136 NX
Skin	136 NX

Bipolar cells	92 NX
Eye	92 NX

Cardiomyocytes	36 NX
Heart muscle	36 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	67 NX
Lung	67 NX

Club cells	85 NX
Lung	85 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	122 NX
Eye	122 NX

Cytotrophoblasts	85 NX
Placenta	85 NX

Distal tubular cells	63 NX
Kidney	63 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	33 NX
Testis	33 NX

Endothelial cells	75 NX
Skin	96 NX
Prostate	92 NX
Eye	86 NX
Testis	77 NX
Pancreas	75 NX
Lung	67 NX
Heart muscle	64 NX
Placenta	53 NX
Liver	32 NX

Enterocytes	27 NX
Small intestine	37 NX
Rectum	29 NX
Colon	14 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	62 NX
Placenta	62 NX

Fibroblasts	101 NX
Skin	201 NX
Prostate	101 NX
Placenta	90 NX
Heart muscle	65 NX
Lung	59 NX

Glandular cells	92 NX
Prostate	92 NX

Granulocytes	55 NX
Lung	56 NX
Colon	55 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	286 NX
Placenta	286 NX

Horizontal cells	81 NX
Eye	81 NX

Intestinal endocrine cells	75 NX
Colon	85 NX
Rectum	66 NX

Ito cells	51 NX
Liver	51 NX

Kupffer cells	182 NX
Liver	181 NX

Late spermatids	47 NX
Testis	47 NX

Leydig cells	125 NX
Testis	125 NX

Macrophages	206 NX
Testis	472 NX
Skin	418 NX
Lung	206 NX
Pancreas	164 NX
Kidney	140 NX
Prostate	103 NX

Melanocytes	76 NX
Skin	76 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	87 NX
Pancreas	87 NX

Mucus-secreting cells	45 NX
Rectum	55 NX
Small intestine	43 NX
Colon	40 NX

Muller glia cells	97 NX
Eye	97 NX

Pancreatic endocrine cells	65 NX
Pancreas	65 NX

Paneth cells	39 NX
Rectum	40 NX
Small intestine	39 NX
Colon	17 NX

Peritubular cells	79 NX
Testis	79 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	104 NX
Eye	104 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	100 NX
Skin	128 NX
Prostate	100 NX
Pancreas	75 NX
Heart muscle	74 NX

Spermatocytes	114 NX
Testis	114 NX

Spermatogonia	139 NX
Testis	139 NX

Suprabasal keratinocytes	96 NX
Skin	96 NX

Syncytiotrophoblasts	70 NX
Placenta	70 NX

T-cells	64 NX
Skin	183 NX
Colon	157 NX
Prostate	113 NX
Lung	105 NX
Kidney	64 NX
Liver	44 NX

Undifferentiated cells	45 NX
Rectum	50 NX
Small intestine	45 NX
Colon	27 NX

Urothelial cells	46 NX
Prostate	46 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.