Cell type atlas - RNF187 - The Human Protein Atlas

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RNF187

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF187
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 187
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Karpas-707, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	13 NX
Lung	13 NX

B-cells	36 NX
Kidney	49 NX
Colon	43 NX
Liver	14 NX

Basal glandular cells	42 NX
Prostate	42 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	84 NX
Eye	84 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	8 NX
Lung	8 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	14 NX
Placenta	14 NX

Distal tubular cells	96 NX
Kidney	96 NX

Ductal cells	14 NX
Pancreas	14 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	23 NX
Skin	42 NX
Eye	35 NX
Liver	25 NX
Prostate	23 NX
Heart muscle	20 NX
Testis	15 NX
Placenta	12 NX
Lung	6 NX
Pancreas	4 NX

Enterocytes	33 NX
Colon	34 NX
Rectum	33 NX
Small intestine	31 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	32 NX
Skin	61 NX
Prostate	37 NX
Heart muscle	32 NX
Placenta	18 NX
Lung	8 NX

Glandular cells	30 NX
Prostate	30 NX

Granulocytes	45 NX
Colon	74 NX
Lung	16 NX

Hepatocytes	56 NX
Liver	56 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	38 NX
Colon	51 NX
Rectum	26 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	30 NX
Liver	30 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	24 NX
Kidney	73 NX
Prostate	36 NX
Skin	31 NX
Lung	15 NX
Testis	14 NX
Pancreas	9 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	6 NX
Pancreas	6 NX

Mucus-secreting cells	27 NX
Colon	46 NX
Rectum	26 NX
Small intestine	25 NX

Muller glia cells	103 NX
Eye	103 NX

Pancreatic endocrine cells	21 NX
Pancreas	21 NX

Paneth cells	20 NX
Colon	32 NX
Rectum	20 NX
Small intestine	11 NX

Peritubular cells	24 NX
Testis	24 NX

Proximal tubular cells	99 NX
Kidney	99 NX

Rod photoreceptor cells	38 NX
Eye	38 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	38 NX
Skin	42 NX
Prostate	38 NX
Pancreas	18 NX
Heart muscle	10 NX

Spermatocytes	4 NX
Testis	4 NX

Spermatogonia	22 NX
Testis	22 NX

Suprabasal keratinocytes	48 NX
Skin	48 NX

Syncytiotrophoblasts	15 NX
Placenta	15 NX

T-cells	42 NX
Kidney	75 NX
Colon	66 NX
Skin	58 NX
Prostate	52 NX
Liver	29 NX
Lung	10 NX

Undifferentiated cells	28 NX
Colon	55 NX
Rectum	23 NX
Small intestine	21 NX

Urothelial cells	25 NX
Prostate	25 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.