Cell type atlas - SETD5 - The Human Protein Atlas

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SETD5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SETD5
Gene descriptionⁱ Full gene name according to HGNC.	SET domain containing 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	45 NX
Lung	45 NX

B-cells	34 NX
Colon	61 NX
Liver	32 NX
Kidney	27 NX

Basal glandular cells	47 NX
Prostate	47 NX

Basal keratinocytes	84 NX
Skin	84 NX

Bipolar cells	110 NX
Eye	110 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	56 NX
Lung	56 NX

Club cells	59 NX
Lung	59 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	108 NX
Eye	108 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	57 NX
Prostate	106 NX
Skin	80 NX
Testis	65 NX
Lung	61 NX
Eye	57 NX
Liver	54 NX
Heart muscle	46 NX
Placenta	43 NX
Pancreas	11 NX

Enterocytes	35 NX
Colon	37 NX
Small intestine	35 NX
Rectum	34 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	30 NX
Pancreas	30 NX

Extravillous trophoblasts	34 NX
Placenta	34 NX

Fibroblasts	56 NX
Prostate	84 NX
Skin	82 NX
Lung	56 NX
Heart muscle	53 NX
Placenta	39 NX

Glandular cells	68 NX
Prostate	68 NX

Granulocytes	46 NX
Lung	56 NX
Colon	37 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	21 NX
Placenta	21 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	60 NX
Rectum	66 NX
Colon	54 NX

Ito cells	57 NX
Liver	57 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	62 NX
Testis	62 NX

Macrophages	31 NX
Skin	55 NX
Lung	36 NX
Prostate	33 NX
Testis	27 NX
Pancreas	26 NX
Kidney	22 NX

Melanocytes	42 NX
Skin	42 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	31 NX
Pancreas	31 NX

Mucus-secreting cells	47 NX
Rectum	48 NX
Small intestine	47 NX
Colon	46 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	46 NX
Rectum	49 NX
Small intestine	46 NX
Colon	32 NX

Peritubular cells	51 NX
Testis	51 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	63 NX
Eye	63 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	58 NX
Skin	61 NX
Prostate	58 NX
Heart muscle	40 NX
Pancreas	31 NX

Spermatocytes	38 NX
Testis	38 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	80 NX
Skin	80 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	51 NX
Skin	63 NX
Liver	57 NX
Lung	48 NX
Colon	48 NX
Prostate	39 NX
Kidney	34 NX

Undifferentiated cells	42 NX
Rectum	44 NX
Small intestine	38 NX
Colon	31 NX

Urothelial cells	64 NX
Prostate	64 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.