Cell type atlas - PAFAH1B2 - The Human Protein Atlas

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PAFAH1B2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PAFAH1B2
Gene descriptionⁱ Full gene name according to HGNC.	Platelet activating factor acetylhydrolase 1b catalytic subunit 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	33 NX
Lung	33 NX

B-cells	41 NX
Colon	75 NX
Kidney	40 NX
Liver	38 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	109 NX
Skin	109 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	31 NX
Heart muscle	31 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	26 NX
Lung	26 NX

Collecting duct cells	63 NX
Kidney	63 NX

Cone photoreceptor cells	45 NX
Eye	45 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	40 NX
Kidney	40 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	54 NX
Skin	110 NX
Liver	103 NX
Testis	77 NX
Prostate	61 NX
Placenta	54 NX
Pancreas	47 NX
Eye	47 NX
Heart muscle	46 NX
Lung	26 NX

Enterocytes	32 NX
Rectum	59 NX
Colon	31 NX
Small intestine	31 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	35 NX
Pancreas	34 NX

Extravillous trophoblasts	77 NX
Placenta	77 NX

Fibroblasts	43 NX
Skin	75 NX
Heart muscle	58 NX
Placenta	36 NX
Prostate	35 NX
Lung	29 NX

Glandular cells	54 NX
Prostate	54 NX

Granulocytes	19 NX
Lung	19 NX
Colon	18 NX

Hepatocytes	39 NX
Liver	39 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	79 NX
Colon	88 NX
Rectum	70 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	60 NX
Liver	60 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	42 NX
Testis	42 NX

Macrophages	56 NX
Skin	120 NX
Kidney	62 NX
Testis	55 NX
Pancreas	52 NX
Prostate	51 NX
Lung	38 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	50 NX
Pancreas	50 NX

Mucus-secreting cells	37 NX
Rectum	46 NX
Small intestine	36 NX
Colon	32 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	73 NX
Pancreas	73 NX

Paneth cells	47 NX
Small intestine	60 NX
Rectum	47 NX
Colon	32 NX

Peritubular cells	32 NX
Testis	32 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	46 NX
Skin	63 NX
Pancreas	49 NX
Heart muscle	33 NX
Prostate	19 NX

Spermatocytes	45 NX
Testis	45 NX

Spermatogonia	76 NX
Testis	76 NX

Suprabasal keratinocytes	101 NX
Skin	101 NX

Syncytiotrophoblasts	46 NX
Placenta	46 NX

T-cells	39 NX
Skin	108 NX
Kidney	40 NX
Colon	39 NX
Liver	37 NX
Prostate	31 NX
Lung	16 NX

Undifferentiated cells	39 NX
Colon	40 NX
Rectum	39 NX
Small intestine	35 NX

Urothelial cells	39 NX
Prostate	39 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.