Cell type atlas - RPSA - The Human Protein Atlas

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RPSA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPSA
Gene descriptionⁱ Full gene name according to HGNC.	Ribosomal protein SA
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Ribosomal proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	482 NX
Lung	482 NX

Alveolar cells type 2	691 NX
Lung	691 NX

B-cells	2495 NX
Liver	2796 NX
Kidney	2517 NX
Colon	1172 NX

Basal glandular cells	2051 NX
Prostate	2051 NX

Basal keratinocytes	1601 NX
Skin	1601 NX

Bipolar cells	264 NX
Eye	264 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	961 NX
Liver	961 NX

Ciliated cells	541 NX
Lung	541 NX

Club cells	781 NX
Lung	781 NX

Collecting duct cells	309 NX
Kidney	309 NX

Cone photoreceptor cells	90 NX
Eye	90 NX

Cytotrophoblasts	2456 NX
Placenta	2456 NX

Distal tubular cells	841 NX
Kidney	841 NX

Ductal cells	1173 NX
Pancreas	1173 NX

Early spermatids	115 NX
Testis	115 NX

Endothelial cells	935 NX
Prostate	1556 NX
Testis	1322 NX
Placenta	1242 NX
Skin	1055 NX
Liver	987 NX
Pancreas	559 NX
Eye	482 NX
Lung	455 NX
Heart muscle	44 NX

Enterocytes	552 NX
Colon	641 NX
Small intestine	560 NX
Rectum	406 NX

Erythroid cells	584 NX
Liver	584 NX

Exocrine glandular cells	2957 NX
Pancreas	2957 NX

Extravillous trophoblasts	3842 NX
Placenta	3842 NX

Fibroblasts	1035 NX
Placenta	1442 NX
Lung	1173 NX
Prostate	1035 NX
Skin	715 NX
Heart muscle	47 NX

Glandular cells	1574 NX
Prostate	1574 NX

Granulocytes	748 NX
Lung	909 NX
Colon	588 NX

Hepatocytes	620 NX
Liver	620 NX

Hofbauer cells	1469 NX
Placenta	1469 NX

Horizontal cells	164 NX
Eye	164 NX

Intestinal endocrine cells	994 NX
Rectum	1212 NX
Colon	775 NX

Ito cells	761 NX
Liver	761 NX

Kupffer cells	1047 NX
Liver	1047 NX

Late spermatids	195 NX
Testis	195 NX

Leydig cells	1149 NX
Testis	1149 NX

Macrophages	962 NX
Prostate	2448 NX
Testis	1750 NX
Skin	1133 NX
Kidney	1033 NX
Pancreas	695 NX
Lung	640 NX

Melanocytes	700 NX
Skin	700 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1430 NX
Pancreas	1430 NX

Mucus-secreting cells	1772 NX
Rectum	2287 NX
Colon	1453 NX
Small intestine	1198 NX

Muller glia cells	254 NX
Eye	254 NX

Pancreatic endocrine cells	1914 NX
Pancreas	1914 NX

Paneth cells	673 NX
Rectum	2036 NX
Small intestine	673 NX
Colon	510 NX

Peritubular cells	703 NX
Testis	703 NX

Proximal tubular cells	848 NX
Kidney	848 NX

Rod photoreceptor cells	249 NX
Eye	249 NX

Sertoli cells	466 NX
Testis	466 NX

Smooth muscle cells	1030 NX
Pancreas	1560 NX
Prostate	1353 NX
Skin	901 NX
Heart muscle	31 NX

Spermatocytes	294 NX
Testis	294 NX

Spermatogonia	1027 NX
Testis	1027 NX

Suprabasal keratinocytes	1675 NX
Skin	1675 NX

Syncytiotrophoblasts	2024 NX
Placenta	2024 NX

T-cells	2013 NX
Liver	2477 NX
Kidney	2024 NX
Skin	2013 NX
Prostate	1809 NX
Colon	987 NX
Lung	965 NX

Undifferentiated cells	2594 NX
Rectum	2632 NX
Small intestine	2627 NX
Colon	1276 NX

Urothelial cells	2441 NX
Prostate	2441 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.