Cell type atlas - EEF2 - The Human Protein Atlas

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EEF2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EEF2
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation elongation factor 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	205 NX
Lung	205 NX

Alveolar cells type 2	340 NX
Lung	340 NX

B-cells	970 NX
Liver	1204 NX
Kidney	958 NX
Colon	738 NX

Basal glandular cells	886 NX
Prostate	886 NX

Basal keratinocytes	1174 NX
Skin	1174 NX

Bipolar cells	200 NX
Eye	200 NX

Cardiomyocytes	547 NX
Heart muscle	547 NX

Cholangiocytes	484 NX
Liver	484 NX

Ciliated cells	158 NX
Lung	158 NX

Club cells	289 NX
Lung	289 NX

Collecting duct cells	243 NX
Kidney	243 NX

Cone photoreceptor cells	73 NX
Eye	73 NX

Cytotrophoblasts	783 NX
Placenta	783 NX

Distal tubular cells	836 NX
Kidney	836 NX

Ductal cells	627 NX
Pancreas	627 NX

Early spermatids	629 NX
Testis	629 NX

Endothelial cells	571 NX
Prostate	907 NX
Skin	808 NX
Liver	789 NX
Testis	718 NX
Placenta	571 NX
Pancreas	448 NX
Eye	271 NX
Lung	225 NX
Heart muscle	183 NX

Enterocytes	714 NX
Small intestine	1349 NX
Colon	640 NX
Rectum	410 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	1561 NX
Pancreas	1561 NX

Extravillous trophoblasts	1076 NX
Placenta	1076 NX

Fibroblasts	819 NX
Skin	953 NX
Prostate	814 NX
Placenta	784 NX
Lung	549 NX
Heart muscle	322 NX

Glandular cells	721 NX
Prostate	721 NX

Granulocytes	367 NX
Colon	432 NX
Lung	302 NX

Hepatocytes	608 NX
Liver	608 NX

Hofbauer cells	546 NX
Placenta	546 NX

Horizontal cells	192 NX
Eye	192 NX

Intestinal endocrine cells	715 NX
Rectum	798 NX
Colon	632 NX

Ito cells	498 NX
Liver	498 NX

Kupffer cells	744 NX
Liver	744 NX

Late spermatids	1008 NX
Testis	1007 NX

Leydig cells	934 NX
Testis	934 NX

Macrophages	543 NX
Prostate	763 NX
Skin	681 NX
Testis	601 NX
Kidney	524 NX
Lung	294 NX
Pancreas	271 NX

Melanocytes	612 NX
Skin	612 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	762 NX
Pancreas	762 NX

Mucus-secreting cells	931 NX
Rectum	979 NX
Colon	918 NX
Small intestine	728 NX

Muller glia cells	218 NX
Eye	218 NX

Pancreatic endocrine cells	963 NX
Pancreas	963 NX

Paneth cells	717 NX
Rectum	912 NX
Colon	717 NX
Small intestine	579 NX

Peritubular cells	783 NX
Testis	783 NX

Proximal tubular cells	714 NX
Kidney	714 NX

Rod photoreceptor cells	97 NX
Eye	97 NX

Sertoli cells	576 NX
Testis	576 NX

Smooth muscle cells	971 NX
Prostate	1210 NX
Skin	1044 NX
Pancreas	971 NX
Heart muscle	208 NX

Spermatocytes	260 NX
Testis	260 NX

Spermatogonia	261 NX
Testis	261 NX

Suprabasal keratinocytes	1178 NX
Skin	1178 NX

Syncytiotrophoblasts	1040 NX
Placenta	1040 NX

T-cells	756 NX
Skin	943 NX
Liver	852 NX
Kidney	756 NX
Colon	685 NX
Prostate	493 NX
Lung	342 NX

Undifferentiated cells	909 NX
Small intestine	1197 NX
Rectum	909 NX
Colon	771 NX

Urothelial cells	772 NX
Prostate	772 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.