Cell type atlas - TPM4 - The Human Protein Atlas

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TPM4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPM4
Gene descriptionⁱ Full gene name according to HGNC.	Tropomyosin 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	372 NX
Lung	372 NX

Alveolar cells type 2	149 NX
Lung	149 NX

B-cells	113 NX
Colon	188 NX
Liver	107 NX
Kidney	67 NX

Basal glandular cells	892 NX
Prostate	892 NX

Basal keratinocytes	383 NX
Skin	383 NX

Bipolar cells	46 NX
Eye	46 NX

Cardiomyocytes	46 NX
Heart muscle	46 NX

Cholangiocytes	97 NX
Liver	97 NX

Ciliated cells	158 NX
Lung	158 NX

Club cells	326 NX
Lung	326 NX

Collecting duct cells	230 NX
Kidney	230 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	212 NX
Placenta	212 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	660 NX
Pancreas	660 NX

Early spermatids	54 NX
Testis	54 NX

Endothelial cells	385 NX
Lung	852 NX
Pancreas	695 NX
Prostate	516 NX
Skin	435 NX
Placenta	385 NX
Liver	227 NX
Testis	187 NX
Eye	171 NX
Heart muscle	136 NX

Enterocytes	203 NX
Colon	348 NX
Rectum	165 NX
Small intestine	51 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	502 NX
Pancreas	502 NX

Extravillous trophoblasts	678 NX
Placenta	678 NX

Fibroblasts	318 NX
Lung	708 NX
Placenta	500 NX
Prostate	299 NX
Skin	286 NX
Heart muscle	165 NX

Glandular cells	567 NX
Prostate	567 NX

Granulocytes	235 NX
Lung	370 NX
Colon	101 NX

Hepatocytes	2 NX
Liver	2 NX

Hofbauer cells	314 NX
Placenta	314 NX

Horizontal cells	5 NX
Eye	5 NX

Intestinal endocrine cells	90 NX
Colon	150 NX
Rectum	31 NX

Ito cells	275 NX
Liver	275 NX

Kupffer cells	103 NX
Liver	103 NX

Late spermatids	37 NX
Testis	37 NX

Leydig cells	160 NX
Testis	160 NX

Macrophages	324 NX
Lung	444 NX
Pancreas	433 NX
Prostate	319 NX
Skin	262 NX
Kidney	147 NX
Testis	118 NX

Melanocytes	135 NX
Skin	135 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	331 NX
Pancreas	331 NX

Mucus-secreting cells	106 NX
Colon	360 NX
Small intestine	104 NX
Rectum	91 NX

Muller glia cells	6 NX
Eye	6 NX

Pancreatic endocrine cells	699 NX
Pancreas	699 NX

Paneth cells	91 NX
Colon	515 NX
Rectum	91 NX
Small intestine	81 NX

Peritubular cells	514 NX
Testis	514 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	330 NX
Testis	330 NX

Smooth muscle cells	424 NX
Pancreas	1071 NX
Prostate	534 NX
Skin	359 NX
Heart muscle	159 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	301 NX
Skin	301 NX

Syncytiotrophoblasts	476 NX
Placenta	476 NX

T-cells	117 NX
Skin	332 NX
Lung	278 NX
Prostate	179 NX
Colon	160 NX
Kidney	117 NX
Liver	64 NX

Undifferentiated cells	89 NX
Colon	243 NX
Small intestine	90 NX
Rectum	82 NX

Urothelial cells	902 NX
Prostate	902 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.