Cell type atlas - VKORC1 - The Human Protein Atlas

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VKORC1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VKORC1
Gene descriptionⁱ Full gene name according to HGNC.	Vitamin K epoxide reductase complex subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	38 NX
Liver	67 NX
Colon	48 NX
Kidney	22 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	75 NX
Skin	75 NX

Bipolar cells	11 NX
Eye	11 NX

Cardiomyocytes	20 NX
Heart muscle	20 NX

Cholangiocytes	120 NX
Liver	120 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	103 NX
Kidney	103 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	64 NX
Placenta	64 NX

Distal tubular cells	53 NX
Kidney	53 NX

Ductal cells	183 NX
Pancreas	183 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	88 NX
Placenta	140 NX
Liver	121 NX
Pancreas	111 NX
Skin	110 NX
Eye	88 NX
Prostate	73 NX
Testis	72 NX
Lung	53 NX
Heart muscle	49 NX

Enterocytes	36 NX
Small intestine	115 NX
Rectum	30 NX
Colon	18 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	112 NX
Pancreas	112 NX

Extravillous trophoblasts	211 NX
Placenta	211 NX

Fibroblasts	139 NX
Skin	188 NX
Placenta	144 NX
Prostate	96 NX
Heart muscle	79 NX
Lung	51 NX

Glandular cells	59 NX
Prostate	59 NX

Granulocytes	55 NX
Colon	83 NX
Lung	28 NX

Hepatocytes	682 NX
Liver	682 NX

Hofbauer cells	166 NX
Placenta	166 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	64 NX
Colon	68 NX
Rectum	61 NX

Ito cells	120 NX
Liver	120 NX

Kupffer cells	79 NX
Liver	79 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	146 NX
Testis	146 NX

Macrophages	85 NX
Pancreas	126 NX
Prostate	100 NX
Kidney	93 NX
Testis	83 NX
Skin	77 NX
Lung	59 NX

Melanocytes	110 NX
Skin	110 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	130 NX
Pancreas	130 NX

Mucus-secreting cells	41 NX
Colon	42 NX
Rectum	41 NX
Small intestine	37 NX

Muller glia cells	65 NX
Eye	65 NX

Pancreatic endocrine cells	107 NX
Pancreas	107 NX

Paneth cells	25 NX
Rectum	38 NX
Small intestine	25 NX
Colon	14 NX

Peritubular cells	162 NX
Testis	162 NX

Proximal tubular cells	160 NX
Kidney	160 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	96 NX
Pancreas	274 NX
Skin	106 NX
Prostate	96 NX
Heart muscle	70 NX

Spermatocytes	24 NX
Testis	24 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	98 NX
Skin	98 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	47 NX
Skin	89 NX
Kidney	76 NX
Colon	57 NX
Liver	41 NX
Lung	36 NX
Prostate	31 NX

Undifferentiated cells	51 NX
Rectum	53 NX
Small intestine	47 NX
Colon	35 NX

Urothelial cells	47 NX
Prostate	47 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.