Expression of PHB in pancreatic cancer - The Human Protein Atlas

PANCREATIC CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

PHB is not prognostic in pancreatic cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 22.32
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

24.0

Number of samples

176

Samples

Sample	Description	FPKM
TCGA-3A-A9I5-01A	58 years, male, white, alive, 1794 days	47.4
TCGA-HV-A7OP-01A	72 years, male, asian, stage:iib, alive, 978 days	45.8
TCGA-S4-A8RO-01A	75 years, female, white, stage:iib, alive, 525 days	45.3
TCGA-XD-AAUI-01A	50 years, female, white, stage:iib, dead, 366 days	43.9
TCGA-IB-A7M4-01A	81 years, male, white, stage:iib, alive, 483 days	43.8
TCGA-2L-AAQM-01A	52 years, male, white, stage:iib, alive, 1383 days	42.2
TCGA-FB-A5VM-01A	74 years, male, white, stage:ib, dead, 498 days	40.4
TCGA-FB-AAQ2-01A	81 years, female, white, stage:iib, dead, 153 days	40.0
TCGA-2L-AAQA-01A	76 years, male, white, stage:iib, dead, 143 days	39.8
TCGA-HV-AA8X-01A	75 years, female, asian, stage:iib, dead, 532 days	38.2
TCGA-HZ-7289-01A	77 years, male, white, stage:iib, dead, 661 days	37.4
TCGA-H8-A6C1-01A	53 years, male, white, stage:iia, alive, 671 days	36.9
TCGA-IB-7646-01A	60 years, male, white, stage:iib, dead, 145 days	35.7
TCGA-HV-A7OL-01A	70 years, male, asian, stage:iia, alive, 252 days	35.5
TCGA-YY-A8LH-01A	61 years, female, white, stage:iib, alive, 2016 days	33.1
TCGA-HZ-8001-01A	69 years, male, white, stage:iii, alive, 706 days	33.0
TCGA-IB-A5SP-01A	77 years, male, white, stage:iia, alive, 482 days	32.9
TCGA-US-A779-01A	54 years, female, white, stage:iib, dead, 511 days	32.9
TCGA-2L-AAQL-01A	82 years, male, white, stage:iib, dead, 292 days	32.4
TCGA-2J-AABP-01A	58 years, female, white, stage:iib, alive, 463 days	32.1
TCGA-3E-AAAZ-01A	71 years, male, white, stage:iia, dead, 2182 days	32.1
TCGA-IB-AAUO-01A	64 years, female, white, stage:iib, dead, 239 days	31.5
TCGA-FB-AAPP-01A	71 years, male, white, stage:iib, dead, 485 days	31.4
TCGA-HZ-7918-01A	72 years, male, white, stage:iib, alive, 969 days	31.2
TCGA-3E-AAAY-01A	67 years, male, white, stage:iib, alive, 2285 days	31.0
TCGA-HZ-A77O-01A	77 years, female, white, stage:iib, dead, 160 days	30.7
TCGA-IB-7889-01A	86 years, female, white, stage:iib, dead, 481 days	30.4
TCGA-2L-AAQI-01A	66 years, male, white, stage:iib, dead, 103 days	30.4
TCGA-HZ-7924-01A	60 years, female, white, stage:iia, alive, 840 days	30.0
TCGA-HZ-A8P1-01A	81 years, male, white, stage:ib, alive, 7 days	29.8
TCGA-FB-AAQ6-01A	85 years, male, white, stage:ia, dead, 244 days	29.8
TCGA-3A-A9J0-01A	75 years, male, white, stage:iib, alive, 743 days	29.7
TCGA-2J-AAB8-01A	71 years, male, white, stage:iib, alive, 80 days	29.7
TCGA-3A-A9IJ-01A	65 years, male, white, stage:ib, alive, 1854 days	29.1
TCGA-FB-AAQ1-01A	49 years, male, white, stage:iib, dead, 123 days	28.3
TCGA-2J-AABO-01A	43 years, male, white, stage:iib, alive, 440 days	28.1
TCGA-F2-A7TX-01A	77 years, male, white, stage:iib, dead, 95 days	27.8
TCGA-LB-A8F3-01A	64 years, female, black or african american, stage:iia, alive, 379 days	27.8
TCGA-2J-AABI-01A	55 years, female, white, stage:iia, alive, 969 days	27.6
TCGA-IB-A5SS-01A	64 years, female, white, stage:iib, dead, 460 days	27.3
TCGA-OE-A75W-01A	75 years, male, white, stage:iia, dead, 267 days	27.2
TCGA-US-A774-01A	76 years, female, white, stage:iib, dead, 695 days	27.2
TCGA-HZ-8638-01A	84 years, female, white, stage:ia, dead, 151 days	27.1
TCGA-3A-A9IB-01A	69 years, female, white, stage:iib, dead, 224 days	27.0
TCGA-F2-A44G-01A	79 years, female, white, stage:iib, dead, 233 days	26.9
TCGA-3A-A9IH-01A	66 years, female, white, stage:ia, alive, 1021 days	26.9
TCGA-FB-A545-01A	72 years, female, white, stage:iib, dead, 732 days	26.8
TCGA-IB-7885-01A	78 years, female, white, stage:iib, alive, 1257 days	26.7
TCGA-2J-AABU-01A	56 years, male, white, stage:iib, dead, 277 days	26.7
TCGA-IB-AAUU-01A	35 years, male, white, stage:iib, alive, 245 days	26.7
TCGA-FB-AAQ3-01A	65 years, female, white, stage:iib, dead, 31 days	26.5
TCGA-HZ-A9TJ-01A	70 years, male, white, stage:iv, alive, 603 days	26.4
TCGA-IB-7651-01A	64 years, female, white, stage:iib, dead, 603 days	26.1
TCGA-FB-AAPU-01A	41 years, female, asian, stage:iia, dead, 381 days	26.0
TCGA-3A-A9IO-01A	56 years, male, white, alive, 1942 days	25.9
TCGA-IB-7893-01A	64 years, male, white, stage:iia, dead, 117 days	25.8
TCGA-FB-AAPQ-01A	65 years, male, white, stage:iib, dead, 1130 days	25.8
TCGA-IB-7644-01A	65 years, female, white, stage:iv, dead, 394 days	25.7
TCGA-HZ-8005-01A	81 years, male, white, stage:iib, dead, 120 days	25.5
TCGA-3A-A9IU-01A	65 years, male, white, stage:iib, dead, 458 days	25.4
TCGA-RB-AA9M-01A	43 years, male, white, stage:iib, alive, 286 days	25.3
TCGA-HZ-A77P-01A	77 years, male, white, stage:iib, alive, 330 days	25.3
TCGA-2J-AABH-01A	61 years, male, white, stage:iia, alive, 1287 days	25.1
TCGA-2J-AAB9-01A	71 years, female, white, stage:iib, dead, 627 days	25.0
TCGA-2J-AAB1-01A	65 years, male, white, stage:iib, dead, 66 days	24.9
TCGA-FB-A7DR-01A	48 years, male, asian, stage:iia, dead, 353 days	24.9
TCGA-IB-7887-01A	62 years, female, white, stage:iib, dead, 110 days	24.7
TCGA-PZ-A5RE-01A	44 years, female, white, stage:iib, dead, 470 days	24.7
TCGA-HV-A5A5-01A	61 years, female, asian, stage:iib, alive, 289 days	24.6
TCGA-3A-A9IL-01A	39 years, female, white, stage:i, alive, 2741 days	24.4
TCGA-LB-A7SX-01A	74 years, female, black or african american, stage:iib, dead, 393 days	24.3
TCGA-3A-A9IV-01A	59 years, female, white, stage:ib, alive, 1103 days	24.0
TCGA-IB-7649-01A	73 years, female, stage:iib, dead, 467 days	24.0
TCGA-HZ-A49H-01A	68 years, female, white, stage:iib, alive, 491 days	23.9
TCGA-YH-A8SY-01A	73 years, female, white, alive, 388 days	23.9
TCGA-IB-7645-01A	44 years, female, stage:iib, dead, 1502 days	23.9
TCGA-2L-AAQE-01A	56 years, male, white, stage:iib, dead, 684 days	23.8
TCGA-2J-AABT-01A	72 years, female, white, stage:iib, alive, 319 days	23.8
TCGA-RL-AAAS-01A	60 years, female, white, stage:ib, alive, 9 days	23.7
TCGA-IB-7888-01A	66 years, female, black or african american, stage:iia, dead, 1332 days	23.2
TCGA-IB-A5ST-01A	64 years, female, white, stage:iib, alive, 635 days	23.2
TCGA-HZ-7919-01A	52 years, female, white, stage:iib, dead, 593 days	23.0
TCGA-FB-AAQ0-01A	68 years, male, white, stage:iia, dead, 473 days	22.9
TCGA-LB-A9Q5-01A	63 years, female, white, stage:iib, dead, 313 days	22.9
TCGA-HZ-8002-01A	61 years, male, white, stage:iib, dead, 366 days	22.6
TCGA-US-A77J-01A	81 years, female, white, stage:iib, dead, 568 days	22.6
TCGA-IB-A5SQ-01A	56 years, female, white, stage:ib, dead, 219 days	22.5
TCGA-FB-A78T-01A	71 years, female, white, stage:iib, dead, 375 days	22.5
TCGA-US-A77G-01A	64 years, male, white, stage:iib, dead, 12 days	22.5
TCGA-HV-A5A4-01A	72 years, female, asian, stage:iia, alive, 232 days	22.5
TCGA-3A-A9IZ-01A	47 years, male, white, stage:iib, dead, 308 days	22.4
TCGA-IB-A7LX-01A	57 years, male, white, stage:iib, dead, 250 days	22.4
TCGA-HV-A5A6-01A	65 years, female, asian, stage:iib, dead, 2036 days	22.4
TCGA-FB-A4P5-01A	69 years, female, white, stage:iib, dead, 179 days	22.4
TCGA-HZ-7922-01A	61 years, female, white, stage:iib, alive, 4 days	22.3
TCGA-US-A776-01A	61 years, male, white, stage:iia, alive, 1216 days	22.1
TCGA-HZ-A49I-01A	77 years, male, white, stage:iib, dead, 308 days	22.1
TCGA-IB-8127-01A	59 years, male, white, stage:iib, alive, 522 days	22.0
TCGA-H6-8124-01A	56 years, female, white, stage:iib, alive, 392 days	21.9
TCGA-3A-A9I7-01A	45 years, male, black or african american, stage:iib, alive, 1323 days	21.9
TCGA-FB-AAPY-01A	71 years, male, white, stage:iib, dead, 1059 days	21.7
TCGA-HZ-7926-01A	57 years, male, black or african american, stage:iib, dead, 518 days	21.6
TCGA-RB-A7B8-01A	81 years, female, white, stage:iib, dead, 466 days	21.6
TCGA-2J-AABF-01A	73 years, male, white, stage:iib, dead, 691 days	21.4
TCGA-XN-A8T5-01A	53 years, female, white, stage:ib, alive, 720 days	21.3
TCGA-S4-A8RP-01A	77 years, female, white, stage:iib, dead, 702 days	21.2
TCGA-Z5-AAPL-01A	74 years, female, white, stage:iia, alive, 467 days	20.9
TCGA-HZ-8519-01A	73 years, male, white, stage:ia, alive, 454 days	20.9
TCGA-2J-AABR-01A	60 years, female, white, stage:iia, alive, 438 days	20.8
TCGA-3A-A9IN-01A	62 years, female, white, stage:ib, alive, 2084 days	20.7
TCGA-3A-A9IC-01A	61 years, female, white, stage:iib, dead, 738 days	20.7
TCGA-IB-AAUQ-01A	50 years, male, white, stage:iib, dead, 183 days	20.4
TCGA-HZ-A4BK-01A	72 years, male, white, stage:iib, alive, 657 days	20.3
TCGA-F2-7276-01A	64 years, male, white, stage:iib, dead, 216 days	20.2
TCGA-YB-A89D-01A	59 years, male, white, stage:iib, alive, 350 days	20.2
TCGA-2J-AAB6-01A	75 years, male, white, stage:iia, dead, 293 days	20.2
TCGA-S4-A8RM-01A	67 years, male, white, stage:iib, alive, 737 days	20.1
TCGA-M8-A5N4-01A	48 years, female, stage:iia, alive, 584 days	20.0
TCGA-2J-AAB4-01A	48 years, male, white, stage:iib, alive, 729 days	20.0
TCGA-IB-AAUN-01A	74 years, female, white, stage:ib, dead, 144 days	19.9
TCGA-3A-A9I9-01A	67 years, male, white, stage:iia, dead, 634 days	19.9
TCGA-XD-AAUH-01A	57 years, female, white, stage:iib, alive, 395 days	19.9
TCGA-HZ-7920-01A	71 years, male, white, stage:ib, dead, 236 days	19.9
TCGA-FB-A4P6-01A	54 years, male, white, stage:iib, alive, 767 days	19.8
TCGA-2J-AABA-01A	55 years, male, white, stage:iib, dead, 607 days	19.8
TCGA-2J-AABE-01A	73 years, male, white, stage:iia, alive, 676 days	19.8
TCGA-HZ-A49G-01A	58 years, female, white, stage:iib, alive, 660 days	19.8
TCGA-IB-7886-01A	80 years, male, white, stage:iib, dead, 123 days	19.8
TCGA-IB-AAUS-01A	84 years, female, white, stage:iib, alive, 225 days	19.8
TCGA-IB-AAUW-01A	63 years, female, white, stage:iib, dead, 230 days	19.7
TCGA-IB-7654-01A	80 years, male, white, stage:iib, dead, 476 days	19.7
TCGA-XN-A8T3-01A	67 years, male, white, stage:ib, alive, 951 days	19.7
TCGA-F2-A44H-01A	65 years, male, white, stage:iia, alive, 586 days	19.7
TCGA-XD-AAUL-01A	56 years, male, white, stage:iia, alive, 498 days	19.6
TCGA-HZ-A77Q-01A	55 years, female, white, stage:iib, alive, 33 days	19.5
TCGA-2J-AABK-01A	71 years, male, white, stage:iib, alive, 484 days	19.5
TCGA-HZ-7925-01A	66 years, male, white, stage:iib, dead, 614 days	19.5
TCGA-HZ-8636-01A	58 years, female, white, stage:iv, dead, 545 days	19.5
TCGA-H6-A45N-01A	88 years, female, white, stage:iib, dead, 421 days	19.4
TCGA-FB-AAPZ-01A	54 years, male, white, stage:iib, alive, 716 days	19.4
TCGA-IB-7890-01A	73 years, male, stage:ib, dead, 598 days	19.3
TCGA-IB-AAUT-01A	65 years, male, white, stage:iib, alive, 287 days	19.2
TCGA-IB-7891-01A	49 years, female, white, stage:iib, dead, 913 days	19.0
TCGA-Q3-A5QY-01A	58 years, male, white, stage:iib, alive, 416 days	18.8
TCGA-IB-A5SO-01A	71 years, male, white, stage:iib, dead, 365 days	18.6
TCGA-3A-A9IS-01A	67 years, male, white, stage:ib, alive, 998 days	18.5
TCGA-Q3-AA2A-01A	64 years, female, white, stage:ib, alive, 95 days	18.4
TCGA-3A-A9IX-01A	40 years, male, white, stage:ia, alive, 1037 days	18.3
TCGA-IB-A6UF-01A	63 years, male, white, stage:iib, alive, 666 days	18.3
TCGA-IB-AAUR-01A	67 years, male, white, stage:iib, alive, 338 days	18.2
TCGA-3A-A9IR-01A	64 years, female, white, stage:ib, alive, 1542 days	18.0
TCGA-HV-AA8V-01A	50 years, male, asian, stage:iib, alive, 920 days	17.9
TCGA-HV-A5A3-01A	50 years, male, asian, stage:iia, dead, 128 days	17.9
TCGA-US-A77E-01A	73 years, male, white, stage:iib, dead, 430 days	17.5
TCGA-IB-AAUP-01A	68 years, male, white, stage:iib, alive, 431 days	17.5
TCGA-2L-AAQJ-01A	49 years, female, white, stage:iii, dead, 394 days	17.5
TCGA-L1-A7W4-01A	48 years, female, white, stage:iib, dead, 278 days	17.3
TCGA-IB-A6UG-01A	65 years, male, white, stage:iib, dead, 41 days	17.3
TCGA-F2-A8YN-01A	76 years, male, white, stage:iia, alive, 517 days	17.3
TCGA-IB-7897-01A	54 years, female, white, stage:iib, dead, 486 days	16.8
TCGA-F2-6879-01A	57 years, male, white, stage:iib, dead, 334 days	16.6
TCGA-IB-7652-01A	49 years, female, asian, stage:iib, alive, 1116 days	16.6
TCGA-XD-AAUG-01A	66 years, female, white, stage:iv, alive, 420 days	16.4
TCGA-HZ-8317-01A	69 years, female, white, stage:iib, dead, 378 days	16.2
TCGA-HZ-A4BH-01A	75 years, male, white, stage:iib, alive, 194 days	16.0
TCGA-F2-7273-01A	54 years, male, black or african american, stage:iib, dead, 592 days	15.9
TCGA-IB-AAUV-01A	49 years, male, white, stage:iib, alive, 404 days	15.8
TCGA-HZ-8637-01A	76 years, female, white, stage:iib, dead, 517 days	15.8
TCGA-HZ-8315-01A	54 years, female, white, stage:iia, dead, 299 days	15.6
TCGA-2J-AABV-01A	74 years, male, white, stage:iib, dead, 652 days	14.1
TCGA-HZ-7923-01A	65 years, male, white, stage:iia, alive, 314 days	14.0
TCGA-IB-AAUM-01A	76 years, male, white, stage:iib, alive, 8 days	13.9
TCGA-FB-AAPS-01A	62 years, female, white, stage:iib, alive, 228 days	13.8
TCGA-HZ-8003-01A	65 years, female, white, stage:iib, dead, 596 days	11.0
TCGA-IB-8126-01A	80 years, female, white, stage:iii, alive, 462 days	9.6
TCGA-F2-6880-01A	70 years, male, white, stage:iib, alive, 289 days	8.8
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PANCREATIC CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA003280
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details