Cell type atlas - STAT6 - The Human Protein Atlas

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STAT6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STAT6
Gene descriptionⁱ Full gene name according to HGNC.	Signal transducer and activator of transcription 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	58 NX
Lung	57 NX

B-cells	34 NX
Colon	66 NX
Kidney	27 NX
Liver	27 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	27 NX
Skin	27 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	46 NX
Lung	46 NX

Club cells	47 NX
Lung	47 NX

Collecting duct cells	47 NX
Kidney	47 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	2 NX
Placenta	2 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	30 NX
Heart muscle	54 NX
Liver	45 NX
Testis	41 NX
Lung	41 NX
Prostate	24 NX
Placenta	24 NX
Eye	21 NX
Skin	19 NX
Pancreas	4 NX

Enterocytes	64 NX
Rectum	73 NX
Colon	63 NX
Small intestine	63 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	31 NX
Pancreas	31 NX

Extravillous trophoblasts	8 NX
Placenta	8 NX

Fibroblasts	27 NX
Heart muscle	46 NX
Lung	35 NX
Skin	30 NX
Prostate	24 NX
Placenta	17 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	56 NX
Lung	74 NX
Colon	37 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	32 NX
Rectum	40 NX
Colon	24 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	76 NX
Liver	76 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	55 NX
Testis	55 NX

Macrophages	54 NX
Lung	88 NX
Testis	58 NX
Skin	54 NX
Kidney	50 NX
Prostate	37 NX
Pancreas	28 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	52 NX
Pancreas	52 NX

Mucus-secreting cells	38 NX
Colon	40 NX
Rectum	36 NX
Small intestine	36 NX

Muller glia cells	3 NX
Eye	3 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	49 NX
Colon	81 NX
Small intestine	49 NX
Rectum	41 NX

Peritubular cells	48 NX
Testis	48 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	28 NX
Heart muscle	61 NX
Skin	28 NX
Prostate	27 NX
Pancreas	15 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	5 NX
Placenta	5 NX

T-cells	30 NX
Lung	53 NX
Skin	35 NX
Liver	34 NX
Kidney	30 NX
Colon	16 NX
Prostate	13 NX

Undifferentiated cells	37 NX
Colon	46 NX
Rectum	38 NX
Small intestine	27 NX

Urothelial cells	49 NX
Prostate	49 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.