Cell type atlas - ANPEP - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ANPEP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ANPEP
Gene descriptionⁱ Full gene name according to HGNC.	Alanyl aminopeptidase, membrane
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes, Proximal tubular cells, Cholangiocytes, Exocrine glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1, BJ, BJ hTERT+, fHDF/TERT166, HMC-1, HSkMC, HUVEC TERT2, TIME, U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes, Proximal tubular cells, Cholangiocytes, Exocrine glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	5 NX
Lung	5 NX

B-cells	8 NX
Kidney	31 NX
Liver	7 NX
Colon	3 NX

Basal glandular cells	3 NX
Prostate	3 NX

Basal keratinocytes	9 NX
Skin	9 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	372 NX
Liver	372 NX

Ciliated cells	3 NX
Lung	3 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	10 NX
Placenta	10 NX

Distal tubular cells	37 NX
Kidney	37 NX

Ductal cells	11 NX
Pancreas	11 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	2 NX
Liver	94 NX
Skin	9 NX
Lung	3 NX
Heart muscle	2 NX
Placenta	1 NX
Prostate	1 NX
Eye	0 NX
Testis	0 NX
Pancreas	0 NX

Enterocytes	994 NX
Small intestine	5594 NX
Rectum	284 NX
Colon	213 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	329 NX
Pancreas	329 NX

Extravillous trophoblasts	12 NX
Placenta	12 NX

Fibroblasts	36 NX
Skin	57 NX
Placenta	27 NX
Prostate	20 NX
Lung	5 NX
Heart muscle	4 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	24 NX
Colon	37 NX
Lung	12 NX

Hepatocytes	145 NX
Liver	145 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	3 NX
Colon	3 NX
Rectum	2 NX

Ito cells	102 NX
Liver	102 NX

Kupffer cells	52 NX
Liver	52 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	3 NX
Testis	3 NX

Macrophages	46 NX
Pancreas	204 NX
Kidney	131 NX
Lung	46 NX
Skin	44 NX
Prostate	34 NX
Testis	23 NX

Melanocytes	3 NX
Skin	3 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	40 NX
Pancreas	40 NX

Mucus-secreting cells	11 NX
Small intestine	565 NX
Colon	12 NX
Rectum	8 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	121 NX
Pancreas	121 NX

Paneth cells	202 NX
Small intestine	656 NX
Colon	202 NX
Rectum	17 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	389 NX
Kidney	389 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	5 NX
Pancreas	27 NX
Skin	10 NX
Prostate	5 NX
Heart muscle	1 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	5 NX
Skin	5 NX

Syncytiotrophoblasts	5 NX
Placenta	5 NX

T-cells	1 NX
Kidney	29 NX
Skin	7 NX
Colon	7 NX
Lung	4 NX
Prostate	0 NX
Liver	0 NX

Undifferentiated cells	18 NX
Small intestine	647 NX
Colon	20 NX
Rectum	7 NX

Urothelial cells	1 NX
Prostate	1 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.