Cell type atlas - PPIB - The Human Protein Atlas

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PPIB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPIB
Gene descriptionⁱ Full gene name according to HGNC.	Peptidylprolyl isomerase B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	116 NX
Lung	116 NX

Alveolar cells type 2	168 NX
Lung	168 NX

B-cells	153 NX
Liver	792 NX
Colon	164 NX
Kidney	143 NX

Basal glandular cells	362 NX
Prostate	362 NX

Basal keratinocytes	142 NX
Skin	142 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	280 NX
Liver	280 NX

Ciliated cells	129 NX
Lung	129 NX

Club cells	195 NX
Lung	195 NX

Collecting duct cells	258 NX
Kidney	258 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	547 NX
Placenta	547 NX

Distal tubular cells	76 NX
Kidney	76 NX

Ductal cells	534 NX
Pancreas	534 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	210 NX
Placenta	444 NX
Pancreas	401 NX
Prostate	377 NX
Testis	216 NX
Liver	216 NX
Skin	187 NX
Eye	138 NX
Lung	99 NX
Heart muscle	2 NX

Enterocytes	301 NX
Colon	325 NX
Small intestine	284 NX
Rectum	159 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	496 NX
Pancreas	496 NX

Extravillous trophoblasts	1107 NX
Placenta	1107 NX

Fibroblasts	581 NX
Placenta	942 NX
Prostate	581 NX
Lung	421 NX
Skin	394 NX
Heart muscle	2 NX

Glandular cells	486 NX
Prostate	486 NX

Granulocytes	177 NX
Colon	184 NX
Lung	170 NX

Hepatocytes	432 NX
Liver	432 NX

Hofbauer cells	567 NX
Placenta	567 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	285 NX
Colon	357 NX
Rectum	213 NX

Ito cells	371 NX
Liver	371 NX

Kupffer cells	214 NX
Liver	214 NX

Late spermatids	21 NX
Testis	21 NX

Leydig cells	423 NX
Testis	423 NX

Macrophages	284 NX
Pancreas	468 NX
Prostate	404 NX
Skin	326 NX
Testis	276 NX
Kidney	268 NX
Lung	197 NX

Melanocytes	267 NX
Skin	267 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	286 NX
Pancreas	286 NX

Mucus-secreting cells	314 NX
Colon	954 NX
Rectum	300 NX
Small intestine	268 NX

Muller glia cells	127 NX
Eye	127 NX

Pancreatic endocrine cells	472 NX
Pancreas	472 NX

Paneth cells	327 NX
Colon	334 NX
Rectum	327 NX
Small intestine	256 NX

Peritubular cells	370 NX
Testis	370 NX

Proximal tubular cells	232 NX
Kidney	232 NX

Rod photoreceptor cells	34 NX
Eye	34 NX

Sertoli cells	226 NX
Testis	226 NX

Smooth muscle cells	235 NX
Pancreas	1093 NX
Prostate	380 NX
Skin	196 NX
Heart muscle	4 NX

Spermatocytes	37 NX
Testis	37 NX

Spermatogonia	73 NX
Testis	73 NX

Suprabasal keratinocytes	127 NX
Skin	127 NX

Syncytiotrophoblasts	936 NX
Placenta	936 NX

T-cells	262 NX
Prostate	445 NX
Kidney	327 NX
Skin	294 NX
Colon	267 NX
Lung	262 NX
Liver	184 NX

Undifferentiated cells	354 NX
Colon	657 NX
Rectum	314 NX
Small intestine	301 NX

Urothelial cells	358 NX
Prostate	358 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.