Cell type atlas - WEE1 - The Human Protein Atlas

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WEE1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WEE1
Gene descriptionⁱ Full gene name according to HGNC.	WEE1 G2 checkpoint kinase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	14 NX
Liver	21 NX
Colon	13 NX
Kidney	9 NX

Basal glandular cells	165 NX
Prostate	165 NX

Basal keratinocytes	157 NX
Skin	157 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	53 NX
Heart muscle	53 NX

Cholangiocytes	66 NX
Liver	66 NX

Ciliated cells	50 NX
Lung	50 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	40 NX
Kidney	40 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	78 NX
Placenta	78 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	22 NX
Pancreas	22 NX

Early spermatids	18 NX
Testis	18 NX

Endothelial cells	13 NX
Skin	44 NX
Prostate	21 NX
Liver	20 NX
Heart muscle	15 NX
Placenta	11 NX
Testis	8 NX
Eye	8 NX
Pancreas	4 NX
Lung	3 NX

Enterocytes	34 NX
Colon	51 NX
Rectum	30 NX
Small intestine	26 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	155 NX
Placenta	155 NX

Fibroblasts	39 NX
Lung	57 NX
Placenta	46 NX
Heart muscle	45 NX
Prostate	39 NX
Skin	28 NX

Glandular cells	76 NX
Prostate	76 NX

Granulocytes	7 NX
Colon	9 NX
Lung	5 NX

Hepatocytes	86 NX
Liver	86 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	59 NX
Colon	105 NX
Rectum	12 NX

Ito cells	9 NX
Liver	9 NX

Kupffer cells	2 NX
Liver	2 NX

Late spermatids	30 NX
Testis	30 NX

Leydig cells	11 NX
Testis	11 NX

Macrophages	8 NX
Prostate	22 NX
Skin	18 NX
Lung	8 NX
Testis	3 NX
Pancreas	2 NX
Kidney	1 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	3 NX
Pancreas	3 NX

Mucus-secreting cells	32 NX
Colon	109 NX
Small intestine	37 NX
Rectum	29 NX

Muller glia cells	9 NX
Eye	9 NX

Pancreatic endocrine cells	21 NX
Pancreas	21 NX

Paneth cells	26 NX
Colon	66 NX
Rectum	26 NX
Small intestine	11 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	22 NX
Prostate	32 NX
Heart muscle	22 NX
Skin	21 NX
Pancreas	10 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	53 NX
Testis	53 NX

Suprabasal keratinocytes	167 NX
Skin	167 NX

Syncytiotrophoblasts	115 NX
Placenta	115 NX

T-cells	13 NX
Skin	39 NX
Colon	18 NX
Prostate	13 NX
Liver	12 NX
Kidney	12 NX
Lung	2 NX

Undifferentiated cells	37 NX
Colon	58 NX
Small intestine	40 NX
Rectum	32 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.