Cell type atlas - TPP1 - The Human Protein Atlas

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TPP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TPP1
Gene descriptionⁱ Full gene name according to HGNC.	Tripeptidyl peptidase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	62 NX
Colon	84 NX
Kidney	54 NX
Liver	49 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	35 NX
Heart muscle	35 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	32 NX
Pancreas	32 NX

Early spermatids	10 NX
Testis	10 NX

Endothelial cells	39 NX
Eye	51 NX
Liver	47 NX
Placenta	44 NX
Testis	39 NX
Skin	39 NX
Lung	38 NX
Heart muscle	36 NX
Prostate	28 NX
Pancreas	18 NX

Enterocytes	51 NX
Small intestine	89 NX
Rectum	64 NX
Colon	33 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	37 NX
Placenta	37 NX

Fibroblasts	30 NX
Prostate	34 NX
Heart muscle	33 NX
Skin	33 NX
Lung	29 NX
Placenta	28 NX

Glandular cells	26 NX
Prostate	26 NX

Granulocytes	62 NX
Colon	92 NX
Lung	33 NX

Hepatocytes	64 NX
Liver	64 NX

Hofbauer cells	224 NX
Placenta	224 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	16 NX
Colon	20 NX
Rectum	12 NX

Ito cells	91 NX
Liver	91 NX

Kupffer cells	312 NX
Liver	312 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	25 NX
Testis	25 NX

Macrophages	116 NX
Prostate	253 NX
Kidney	181 NX
Lung	136 NX
Testis	116 NX
Skin	109 NX
Pancreas	91 NX

Melanocytes	86 NX
Skin	86 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	64 NX
Pancreas	64 NX

Mucus-secreting cells	29 NX
Small intestine	31 NX
Rectum	31 NX
Colon	20 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	19 NX
Pancreas	19 NX

Paneth cells	39 NX
Small intestine	53 NX
Rectum	39 NX
Colon	29 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	46 NX
Kidney	46 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	23 NX
Prostate	32 NX
Heart muscle	26 NX
Skin	22 NX
Pancreas	20 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	74 NX
Placenta	74 NX

T-cells	45 NX
Lung	59 NX
Prostate	48 NX
Liver	47 NX
Kidney	43 NX
Colon	43 NX
Skin	32 NX

Undifferentiated cells	28 NX
Rectum	34 NX
Small intestine	28 NX
Colon	21 NX

Urothelial cells	23 NX
Prostate	23 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.