Cell type atlas - CKB - The Human Protein Atlas

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CKB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CKB
Gene descriptionⁱ Full gene name according to HGNC.	Creatine kinase B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells, Muller glia cells, Rod photoreceptor cells, Bipolar cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CACO-2, HEK93, SCLC-21H)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells, Muller glia cells, Rod photoreceptor cells, Bipolar cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	182 NX
Lung	182 NX

Alveolar cells type 2	96 NX
Lung	96 NX

B-cells	16 NX
Colon	60 NX
Kidney	22 NX
Liver	5 NX

Basal glandular cells	252 NX
Prostate	252 NX

Basal keratinocytes	137 NX
Skin	137 NX

Bipolar cells	2314 NX
Eye	2314 NX

Cardiomyocytes	490 NX
Heart muscle	490 NX

Cholangiocytes	117 NX
Liver	117 NX

Ciliated cells	301 NX
Lung	301 NX

Club cells	83 NX
Lung	83 NX

Collecting duct cells	108 NX
Kidney	108 NX

Cone photoreceptor cells	1799 NX
Eye	1799 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	1933 NX
Kidney	1933 NX

Ductal cells	99 NX
Pancreas	99 NX

Early spermatids	398 NX
Testis	398 NX

Endothelial cells	37 NX
Eye	431 NX
Heart muscle	104 NX
Liver	67 NX
Testis	40 NX
Skin	31 NX
Prostate	25 NX
Lung	6 NX
Placenta	3 NX
Pancreas	0 NX

Enterocytes	717 NX
Rectum	7167 NX
Colon	1048 NX
Small intestine	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	38 NX
Pancreas	37 NX

Extravillous trophoblasts	10 NX
Placenta	10 NX

Fibroblasts	100 NX
Heart muscle	201 NX
Prostate	168 NX
Skin	104 NX
Lung	60 NX
Placenta	55 NX

Glandular cells	317 NX
Prostate	317 NX

Granulocytes	29 NX
Colon	46 NX
Lung	12 NX

Hepatocytes	7 NX
Liver	7 NX

Hofbauer cells	7 NX
Placenta	7 NX

Horizontal cells	4762 NX
Eye	4762 NX

Intestinal endocrine cells	450 NX
Rectum	658 NX
Colon	241 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	3 NX
Liver	3 NX

Late spermatids	120 NX
Testis	120 NX

Leydig cells	282 NX
Testis	282 NX

Macrophages	32 NX
Pancreas	126 NX
Prostate	69 NX
Kidney	41 NX
Skin	33 NX
Testis	15 NX
Lung	13 NX

Melanocytes	172 NX
Skin	172 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	123 NX
Pancreas	123 NX

Mucus-secreting cells	614 NX
Colon	751 NX
Rectum	645 NX
Small intestine	90 NX

Muller glia cells	3353 NX
Eye	3353 NX

Pancreatic endocrine cells	99 NX
Pancreas	99 NX

Paneth cells	2060 NX
Colon	2683 NX
Rectum	2060 NX
Small intestine	603 NX

Peritubular cells	1024 NX
Testis	1024 NX

Proximal tubular cells	70 NX
Kidney	70 NX

Rod photoreceptor cells	2842 NX
Eye	2842 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	194 NX
Prostate	481 NX
Heart muscle	194 NX
Skin	179 NX
Pancreas	12 NX

Spermatocytes	161 NX
Testis	161 NX

Spermatogonia	93 NX
Testis	93 NX

Suprabasal keratinocytes	153 NX
Skin	153 NX

Syncytiotrophoblasts	35 NX
Placenta	35 NX

T-cells	12 NX
Colon	84 NX
Prostate	39 NX
Skin	34 NX
Lung	14 NX
Kidney	12 NX
Liver	4 NX

Undifferentiated cells	563 NX
Rectum	906 NX
Colon	505 NX
Small intestine	23 NX

Urothelial cells	195 NX
Prostate	195 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.