Cell type atlas - HTRA1 - The Human Protein Atlas

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HTRA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HTRA1
Gene descriptionⁱ Full gene name according to HGNC.	HtrA serine peptidase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Horizontal cells, Muller glia cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (classical monocyte, memory CD4 T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC, LHCN-M2, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Horizontal cells, Muller glia cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	0 NX
Liver	6 NX
Kidney	0 NX
Colon	0 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	55 NX
Eye	55 NX

Cardiomyocytes	23 NX
Heart muscle	23 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	0 NX
Lung	0 NX

Collecting duct cells	61 NX
Kidney	61 NX

Cone photoreceptor cells	51 NX
Eye	51 NX

Cytotrophoblasts	16 NX
Placenta	16 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	2 NX
Pancreas	2 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	65 NX
Testis	130 NX
Eye	122 NX
Skin	84 NX
Pancreas	79 NX
Placenta	77 NX
Liver	61 NX
Lung	44 NX
Prostate	25 NX
Heart muscle	18 NX

Enterocytes	0 NX
Colon	0 NX
Rectum	0 NX
Small intestine	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	4 NX
Pancreas	4 NX

Extravillous trophoblasts	128 NX
Placenta	128 NX

Fibroblasts	77 NX
Skin	480 NX
Prostate	81 NX
Placenta	48 NX
Heart muscle	46 NX
Lung	9 NX

Glandular cells	9 NX
Prostate	9 NX

Granulocytes	1 NX
Lung	2 NX
Colon	0 NX

Hepatocytes	86 NX
Liver	86 NX

Hofbauer cells	53 NX
Placenta	53 NX

Horizontal cells	591 NX
Eye	591 NX

Intestinal endocrine cells	0 NX
Colon	0 NX
Rectum	0 NX

Ito cells	55 NX
Liver	55 NX

Kupffer cells	17 NX
Liver	17 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	29 NX
Testis	29 NX

Macrophages	7 NX
Skin	46 NX
Prostate	36 NX
Testis	8 NX
Pancreas	7 NX
Kidney	5 NX
Lung	3 NX

Melanocytes	44 NX
Skin	44 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	13 NX
Pancreas	13 NX

Mucus-secreting cells	0 NX
Small intestine	1 NX
Colon	0 NX
Rectum	0 NX

Muller glia cells	269 NX
Eye	269 NX

Pancreatic endocrine cells	4 NX
Pancreas	4 NX

Paneth cells	0 NX
Small intestine	4 NX
Rectum	0 NX
Colon	0 NX

Peritubular cells	73 NX
Testis	73 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	111 NX
Eye	110 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	60 NX
Pancreas	127 NX
Skin	67 NX
Prostate	58 NX
Heart muscle	27 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	27 NX
Skin	27 NX

Syncytiotrophoblasts	73 NX
Placenta	73 NX

T-cells	5 NX
Skin	36 NX
Prostate	13 NX
Kidney	5 NX
Colon	5 NX
Lung	3 NX
Liver	0 NX

Undifferentiated cells	0 NX
Small intestine	1 NX
Rectum	0 NX
Colon	0 NX

Urothelial cells	13 NX
Prostate	13 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.