Cell type atlas - ARL5B - The Human Protein Atlas

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ARL5B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ARL5B
Gene descriptionⁱ Full gene name according to HGNC.	ADP ribosylation factor like GTPase 5B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	24 NX
Lung	24 NX

B-cells	26 NX
Colon	63 NX
Liver	26 NX
Kidney	5 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	135 NX
Skin	135 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	6 NX
Eye	6 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	5 NX
Kidney	5 NX

Ductal cells	20 NX
Pancreas	20 NX

Early spermatids	36 NX
Testis	36 NX

Endothelial cells	23 NX
Skin	132 NX
Prostate	81 NX
Eye	37 NX
Heart muscle	36 NX
Liver	18 NX
Placenta	17 NX
Lung	15 NX
Testis	14 NX
Pancreas	4 NX

Enterocytes	70 NX
Colon	136 NX
Small intestine	46 NX
Rectum	29 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	27 NX
Placenta	27 NX

Fibroblasts	50 NX
Prostate	90 NX
Skin	73 NX
Lung	50 NX
Placenta	15 NX
Heart muscle	15 NX

Glandular cells	52 NX
Prostate	52 NX

Granulocytes	102 NX
Colon	175 NX
Lung	30 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	12 NX
Placenta	12 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	63 NX
Colon	102 NX
Rectum	23 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	18 NX
Liver	18 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	20 NX
Skin	225 NX
Prostate	119 NX
Testis	16 NX
Lung	15 NX
Kidney	14 NX
Pancreas	7 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	29 NX
Colon	116 NX
Small intestine	34 NX
Rectum	21 NX

Muller glia cells	10 NX
Eye	10 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	20 NX
Colon	181 NX
Rectum	20 NX
Small intestine	14 NX

Peritubular cells	5 NX
Testis	5 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	69 NX
Skin	96 NX
Prostate	69 NX
Heart muscle	33 NX
Pancreas	7 NX

Spermatocytes	20 NX
Testis	20 NX

Spermatogonia	15 NX
Testis	15 NX

Suprabasal keratinocytes	146 NX
Skin	146 NX

Syncytiotrophoblasts	36 NX
Placenta	36 NX

T-cells	13 NX
Skin	99 NX
Colon	66 NX
Prostate	26 NX
Lung	14 NX
Kidney	6 NX
Liver	4 NX

Undifferentiated cells	22 NX
Colon	46 NX
Small intestine	27 NX
Rectum	18 NX

Urothelial cells	127 NX
Prostate	127 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.