Cell type atlas - TC2N - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TC2N

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TC2N
Gene descriptionⁱ Full gene name according to HGNC.	Tandem C2 domains, nuclear
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (MAIT T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CAPAN-2, OE19, RT4, SK-BR-3, T-47d)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	71 NX
Lung	71 NX

B-cells	7 NX
Kidney	9 NX
Liver	8 NX
Colon	5 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	48 NX
Skin	48 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	68 NX
Lung	68 NX

Club cells	59 NX
Lung	59 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	56 NX
Pancreas	56 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	4 NX
Skin	72 NX
Lung	32 NX
Heart muscle	8 NX
Testis	5 NX
Prostate	4 NX
Liver	0 NX
Pancreas	0 NX
Eye	0 NX
Placenta	0 NX

Enterocytes	23 NX
Colon	47 NX
Rectum	42 NX
Small intestine	17 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	183 NX
Pancreas	183 NX

Extravillous trophoblasts	3 NX
Placenta	3 NX

Fibroblasts	11 NX
Heart muscle	39 NX
Skin	16 NX
Prostate	12 NX
Lung	10 NX
Placenta	1 NX

Glandular cells	49 NX
Prostate	49 NX

Granulocytes	7 NX
Colon	9 NX
Lung	5 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	0 NX
Placenta	0 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	31 NX
Rectum	31 NX
Colon	31 NX

Ito cells	6 NX
Liver	6 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	53 NX
Testis	53 NX

Macrophages	2 NX
Skin	8 NX
Lung	7 NX
Kidney	2 NX
Testis	1 NX
Prostate	0 NX
Pancreas	0 NX

Melanocytes	57 NX
Skin	57 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1 NX
Pancreas	1 NX

Mucus-secreting cells	55 NX
Colon	61 NX
Rectum	49 NX
Small intestine	45 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	111 NX
Pancreas	110 NX

Paneth cells	41 NX
Colon	49 NX
Rectum	41 NX
Small intestine	18 NX

Peritubular cells	12 NX
Testis	12 NX

Proximal tubular cells	8 NX
Kidney	8 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	4 NX
Prostate	6 NX
Skin	5 NX
Pancreas	4 NX
Heart muscle	1 NX

Spermatocytes	35 NX
Testis	35 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	72 NX
Skin	72 NX

Syncytiotrophoblasts	5 NX
Placenta	5 NX

T-cells	55 NX
Skin	105 NX
Kidney	71 NX
Colon	71 NX
Lung	55 NX
Liver	41 NX
Prostate	22 NX

Undifferentiated cells	33 NX
Colon	68 NX
Rectum	34 NX
Small intestine	24 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.