Cell type atlas - NSD1 - The Human Protein Atlas

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NSD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NSD1
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear receptor binding SET domain protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	42 NX
Kidney	94 NX
Colon	60 NX
Liver	13 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	92 NX
Eye	92 NX

Cardiomyocytes	38 NX
Heart muscle	38 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	52 NX
Kidney	52 NX

Cone photoreceptor cells	141 NX
Eye	141 NX

Cytotrophoblasts	35 NX
Placenta	35 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	23 NX
Pancreas	23 NX

Early spermatids	26 NX
Testis	26 NX

Endothelial cells	32 NX
Heart muscle	53 NX
Lung	47 NX
Liver	36 NX
Placenta	33 NX
Prostate	32 NX
Testis	31 NX
Eye	24 NX
Skin	19 NX
Pancreas	14 NX

Enterocytes	22 NX
Small intestine	29 NX
Colon	18 NX
Rectum	16 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	19 NX
Pancreas	18 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	23 NX
Heart muscle	37 NX
Placenta	31 NX
Prostate	23 NX
Lung	23 NX
Skin	17 NX

Glandular cells	24 NX
Prostate	24 NX

Granulocytes	39 NX
Lung	60 NX
Colon	18 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	84 NX
Eye	84 NX

Intestinal endocrine cells	40 NX
Colon	41 NX
Rectum	40 NX

Ito cells	31 NX
Liver	31 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	34 NX
Testis	34 NX

Leydig cells	47 NX
Testis	47 NX

Macrophages	39 NX
Kidney	50 NX
Lung	45 NX
Pancreas	37 NX
Prostate	32 NX
Skin	31 NX
Testis	26 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	51 NX
Pancreas	51 NX

Mucus-secreting cells	19 NX
Small intestine	36 NX
Colon	18 NX
Rectum	18 NX

Muller glia cells	36 NX
Eye	36 NX

Pancreatic endocrine cells	20 NX
Pancreas	20 NX

Paneth cells	25 NX
Small intestine	49 NX
Rectum	25 NX
Colon	12 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	14 NX
Kidney	14 NX

Rod photoreceptor cells	100 NX
Eye	100 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	20 NX
Heart muscle	45 NX
Pancreas	24 NX
Prostate	19 NX
Skin	18 NX

Spermatocytes	63 NX
Testis	63 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	30 NX
Placenta	30 NX

T-cells	51 NX
Kidney	74 NX
Colon	69 NX
Liver	57 NX
Prostate	48 NX
Lung	45 NX
Skin	33 NX

Undifferentiated cells	22 NX
Small intestine	26 NX
Colon	24 NX
Rectum	21 NX

Urothelial cells	24 NX
Prostate	24 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.