Cell type atlas - AQP3 - The Human Protein Atlas

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AQP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AQP3
Gene descriptionⁱ Full gene name according to HGNC.	Aquaporin 3 (Gill blood group)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Blood group antigen proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Suprabasal keratinocytes, Urothelial cells, Basal keratinocytes, Collecting duct cells, Glandular cells, Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (T-reg, MAIT T-cell, memory CD4 T-cell, naive CD4 T-cell, memory CD8 T-cell, naive CD8 T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HaCaT, HeLa, JURKAT, RT4, SK-BR-3, U-266/70, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Suprabasal keratinocytes, Urothelial cells, Basal keratinocytes, Collecting duct cells, Glandular cells, Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	265 NX
Lung	265 NX

B-cells	2 NX
Liver	119 NX
Kidney	5 NX
Colon	0 NX

Basal glandular cells	609 NX
Prostate	609 NX

Basal keratinocytes	1709 NX
Skin	1709 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	2 NX
Heart muscle	2 NX

Cholangiocytes	104 NX
Liver	104 NX

Ciliated cells	137 NX
Lung	137 NX

Club cells	215 NX
Lung	215 NX

Collecting duct cells	1527 NX
Kidney	1527 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	41 NX
Skin	102 NX
Prostate	83 NX
Heart muscle	76 NX
Liver	41 NX
Eye	19 NX
Placenta	13 NX
Lung	9 NX
Testis	2 NX
Pancreas	0 NX

Enterocytes	4 NX
Small intestine	290 NX
Colon	4 NX
Rectum	1 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	42 NX
Pancreas	42 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	46 NX
Prostate	74 NX
Skin	73 NX
Placenta	39 NX
Heart muscle	12 NX
Lung	11 NX

Glandular cells	960 NX
Prostate	960 NX

Granulocytes	20 NX
Lung	30 NX
Colon	9 NX

Hepatocytes	112 NX
Liver	112 NX

Hofbauer cells	2 NX
Placenta	2 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	8 NX
Colon	14 NX
Rectum	2 NX

Ito cells	16 NX
Liver	16 NX

Kupffer cells	4 NX
Liver	4 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	32 NX
Skin	89 NX
Lung	80 NX
Prostate	36 NX
Pancreas	16 NX
Kidney	3 NX
Testis	0 NX

Melanocytes	150 NX
Skin	150 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1 NX
Pancreas	1 NX

Mucus-secreting cells	64 NX
Small intestine	141 NX
Colon	117 NX
Rectum	44 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	32 NX
Pancreas	32 NX

Paneth cells	3 NX
Small intestine	18 NX
Colon	3 NX
Rectum	2 NX

Peritubular cells	1 NX
Testis	1 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	42 NX
Prostate	70 NX
Skin	46 NX
Heart muscle	18 NX
Pancreas	4 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	2172 NX
Skin	2172 NX

Syncytiotrophoblasts	42 NX
Placenta	42 NX

T-cells	43 NX
Skin	114 NX
Prostate	87 NX
Lung	52 NX
Kidney	43 NX
Colon	40 NX
Liver	22 NX

Undifferentiated cells	4 NX
Small intestine	14 NX
Colon	4 NX
Rectum	1 NX

Urothelial cells	2009 NX
Prostate	2009 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.