Cell type atlas - CTSB - The Human Protein Atlas

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CTSB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTSB
Gene descriptionⁱ Full gene name according to HGNC.	Cathepsin B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Candidate cardiovascular disease genes Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	23

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, intermediate monocyte, plasmacytoid DC, myeloid DC, non-classical monocyte, basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (BJ hTERT+, fHDF/TERT166)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	101 NX
Lung	101 NX

Alveolar cells type 2	206 NX
Lung	206 NX

B-cells	74 NX
Colon	145 NX
Liver	74 NX
Kidney	45 NX

Basal glandular cells	365 NX
Prostate	365 NX

Basal keratinocytes	49 NX
Skin	49 NX

Bipolar cells	44 NX
Eye	44 NX

Cardiomyocytes	252 NX
Heart muscle	252 NX

Cholangiocytes	176 NX
Liver	176 NX

Ciliated cells	138 NX
Lung	138 NX

Club cells	228 NX
Lung	228 NX

Collecting duct cells	108 NX
Kidney	108 NX

Cone photoreceptor cells	39 NX
Eye	39 NX

Cytotrophoblasts	225 NX
Placenta	225 NX

Distal tubular cells	23 NX
Kidney	23 NX

Ductal cells	277 NX
Pancreas	277 NX

Early spermatids	13 NX
Testis	13 NX

Endothelial cells	120 NX
Pancreas	380 NX
Eye	380 NX
Prostate	223 NX
Heart muscle	128 NX
Placenta	126 NX
Lung	120 NX
Liver	103 NX
Skin	66 NX
Testis	65 NX

Enterocytes	153 NX
Small intestine	164 NX
Rectum	129 NX
Colon	106 NX

Erythroid cells	210 NX
Liver	210 NX

Exocrine glandular cells	212 NX
Pancreas	212 NX

Extravillous trophoblasts	281 NX
Placenta	281 NX

Fibroblasts	150 NX
Placenta	191 NX
Prostate	174 NX
Heart muscle	150 NX
Lung	143 NX
Skin	125 NX

Glandular cells	239 NX
Prostate	239 NX

Granulocytes	169 NX
Lung	265 NX
Colon	74 NX

Hepatocytes	204 NX
Liver	204 NX

Hofbauer cells	2618 NX
Placenta	2618 NX

Horizontal cells	56 NX
Eye	56 NX

Intestinal endocrine cells	149 NX
Rectum	199 NX
Colon	99 NX

Ito cells	215 NX
Liver	215 NX

Kupffer cells	1392 NX
Liver	1392 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	71 NX
Testis	71 NX

Macrophages	860 NX
Pancreas	4424 NX
Prostate	1625 NX
Lung	959 NX
Kidney	876 NX
Testis	666 NX
Skin	334 NX

Melanocytes	154 NX
Skin	154 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	400 NX
Pancreas	400 NX

Mucus-secreting cells	81 NX
Small intestine	102 NX
Colon	76 NX
Rectum	71 NX

Muller glia cells	116 NX
Eye	116 NX

Pancreatic endocrine cells	265 NX
Pancreas	265 NX

Paneth cells	109 NX
Colon	199 NX
Small intestine	109 NX
Rectum	107 NX

Peritubular cells	87 NX
Testis	87 NX

Proximal tubular cells	332 NX
Kidney	332 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	121 NX
Pancreas	472 NX
Prostate	151 NX
Heart muscle	121 NX
Skin	63 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	19 NX
Testis	19 NX

Suprabasal keratinocytes	35 NX
Skin	35 NX

Syncytiotrophoblasts	543 NX
Placenta	543 NX

T-cells	51 NX
Lung	191 NX
Kidney	63 NX
Prostate	61 NX
Skin	56 NX
Colon	38 NX
Liver	30 NX

Undifferentiated cells	115 NX
Colon	132 NX
Small intestine	127 NX
Rectum	111 NX

Urothelial cells	284 NX
Prostate	284 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.