Cell type atlas - TRA2A - The Human Protein Atlas

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TRA2A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRA2A
Gene descriptionⁱ Full gene name according to HGNC.	Transformer 2 alpha homolog
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	68 NX
Lung	68 NX

B-cells	70 NX
Colon	117 NX
Kidney	71 NX
Liver	56 NX

Basal glandular cells	86 NX
Prostate	86 NX

Basal keratinocytes	93 NX
Skin	93 NX

Bipolar cells	50 NX
Eye	50 NX

Cardiomyocytes	37 NX
Heart muscle	37 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	78 NX
Lung	78 NX

Club cells	60 NX
Lung	60 NX

Collecting duct cells	84 NX
Kidney	84 NX

Cone photoreceptor cells	49 NX
Eye	49 NX

Cytotrophoblasts	77 NX
Placenta	77 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	48 NX
Pancreas	48 NX

Early spermatids	49 NX
Testis	49 NX

Endothelial cells	63 NX
Skin	86 NX
Liver	81 NX
Prostate	70 NX
Heart muscle	65 NX
Testis	63 NX
Placenta	60 NX
Lung	55 NX
Eye	50 NX
Pancreas	25 NX

Enterocytes	68 NX
Colon	83 NX
Rectum	51 NX
Small intestine	46 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	38 NX
Pancreas	38 NX

Extravillous trophoblasts	71 NX
Placenta	71 NX

Fibroblasts	87 NX
Lung	108 NX
Skin	92 NX
Prostate	87 NX
Heart muscle	67 NX
Placenta	65 NX

Glandular cells	68 NX
Prostate	68 NX

Granulocytes	83 NX
Lung	102 NX
Colon	64 NX

Hepatocytes	63 NX
Liver	63 NX

Hofbauer cells	49 NX
Placenta	49 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	114 NX
Colon	173 NX
Rectum	54 NX

Ito cells	70 NX
Liver	70 NX

Kupffer cells	87 NX
Liver	87 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	60 NX
Testis	60 NX

Macrophages	74 NX
Skin	101 NX
Prostate	82 NX
Kidney	75 NX
Lung	64 NX
Testis	50 NX
Pancreas	47 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	57 NX
Colon	157 NX
Rectum	58 NX
Small intestine	47 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	49 NX
Pancreas	49 NX

Paneth cells	81 NX
Colon	101 NX
Small intestine	81 NX
Rectum	67 NX

Peritubular cells	64 NX
Testis	64 NX

Proximal tubular cells	32 NX
Kidney	32 NX

Rod photoreceptor cells	101 NX
Eye	101 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	79 NX
Skin	97 NX
Prostate	90 NX
Heart muscle	77 NX
Pancreas	42 NX

Spermatocytes	92 NX
Testis	92 NX

Spermatogonia	55 NX
Testis	55 NX

Suprabasal keratinocytes	99 NX
Skin	99 NX

Syncytiotrophoblasts	99 NX
Placenta	99 NX

T-cells	98 NX
Skin	178 NX
Prostate	166 NX
Lung	121 NX
Colon	98 NX
Liver	90 NX
Kidney	55 NX

Undifferentiated cells	62 NX
Colon	124 NX
Small intestine	67 NX
Rectum	59 NX

Urothelial cells	74 NX
Prostate	74 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.