Cell type atlas - CREBRF - The Human Protein Atlas

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CREBRF

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CREBRF
Gene descriptionⁱ Full gene name according to HGNC.	CREB3 regulatory factor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	37 NX
Lung	37 NX

B-cells	34 NX
Colon	130 NX
Kidney	40 NX
Liver	19 NX

Basal glandular cells	21 NX
Prostate	21 NX

Basal keratinocytes	70 NX
Skin	70 NX

Bipolar cells	49 NX
Eye	49 NX

Cardiomyocytes	54 NX
Heart muscle	54 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	37 NX
Kidney	37 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	12 NX
Pancreas	12 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	64 NX
Skin	82 NX
Liver	79 NX
Prostate	75 NX
Eye	73 NX
Lung	61 NX
Heart muscle	60 NX
Testis	51 NX
Placenta	24 NX
Pancreas	18 NX

Enterocytes	34 NX
Rectum	50 NX
Small intestine	36 NX
Colon	34 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	10 NX
Placenta	10 NX

Fibroblasts	43 NX
Skin	87 NX
Heart muscle	78 NX
Prostate	66 NX
Lung	29 NX
Placenta	16 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	46 NX
Lung	56 NX
Colon	37 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	19 NX
Placenta	19 NX

Horizontal cells	107 NX
Eye	107 NX

Intestinal endocrine cells	73 NX
Colon	126 NX
Rectum	21 NX

Ito cells	38 NX
Liver	38 NX

Kupffer cells	67 NX
Liver	67 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	48 NX
Testis	48 NX

Macrophages	51 NX
Testis	67 NX
Prostate	55 NX
Skin	52 NX
Kidney	51 NX
Lung	33 NX
Pancreas	12 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	45 NX
Pancreas	45 NX

Mucus-secreting cells	27 NX
Small intestine	27 NX
Rectum	27 NX
Colon	27 NX

Muller glia cells	36 NX
Eye	36 NX

Pancreatic endocrine cells	16 NX
Pancreas	16 NX

Paneth cells	25 NX
Colon	43 NX
Rectum	25 NX
Small intestine	18 NX

Peritubular cells	52 NX
Testis	52 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	64 NX
Eye	64 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	59 NX
Prostate	65 NX
Skin	62 NX
Heart muscle	59 NX
Pancreas	4 NX

Spermatocytes	64 NX
Testis	64 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	81 NX
Skin	81 NX

Syncytiotrophoblasts	31 NX
Placenta	31 NX

T-cells	53 NX
Colon	100 NX
Skin	62 NX
Lung	53 NX
Liver	47 NX
Prostate	39 NX
Kidney	28 NX

Undifferentiated cells	19 NX
Rectum	20 NX
Small intestine	19 NX
Colon	19 NX

Urothelial cells	19 NX
Prostate	19 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.