Cell type atlas - UQCRQ - The Human Protein Atlas

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UQCRQ

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UQCRQ
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquinol-cytochrome c reductase complex III subunit VII
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	232 NX
Lung	232 NX

Alveolar cells type 2	318 NX
Lung	318 NX

B-cells	276 NX
Liver	617 NX
Kidney	397 NX
Colon	155 NX

Basal glandular cells	310 NX
Prostate	310 NX

Basal keratinocytes	309 NX
Skin	309 NX

Bipolar cells	84 NX
Eye	84 NX

Cardiomyocytes	3256 NX
Heart muscle	3256 NX

Cholangiocytes	1190 NX
Liver	1190 NX

Ciliated cells	321 NX
Lung	321 NX

Club cells	222 NX
Lung	222 NX

Collecting duct cells	747 NX
Kidney	747 NX

Cone photoreceptor cells	114 NX
Eye	114 NX

Cytotrophoblasts	634 NX
Placenta	634 NX

Distal tubular cells	1537 NX
Kidney	1537 NX

Ductal cells	621 NX
Pancreas	621 NX

Early spermatids	357 NX
Testis	357 NX

Endothelial cells	306 NX
Heart muscle	551 NX
Placenta	503 NX
Skin	322 NX
Pancreas	315 NX
Liver	306 NX
Testis	241 NX
Prostate	172 NX
Eye	156 NX
Lung	149 NX

Enterocytes	1715 NX
Small intestine	2022 NX
Rectum	1699 NX
Colon	1163 NX

Erythroid cells	234 NX
Liver	234 NX

Exocrine glandular cells	827 NX
Pancreas	827 NX

Extravillous trophoblasts	363 NX
Placenta	363 NX

Fibroblasts	375 NX
Heart muscle	864 NX
Placenta	466 NX
Skin	331 NX
Lung	281 NX
Prostate	142 NX

Glandular cells	616 NX
Prostate	616 NX

Granulocytes	286 NX
Lung	305 NX
Colon	266 NX

Hepatocytes	4284 NX
Liver	4284 NX

Hofbauer cells	668 NX
Placenta	668 NX

Horizontal cells	68 NX
Eye	68 NX

Intestinal endocrine cells	528 NX
Rectum	552 NX
Colon	503 NX

Ito cells	324 NX
Liver	324 NX

Kupffer cells	428 NX
Liver	428 NX

Late spermatids	786 NX
Testis	786 NX

Leydig cells	262 NX
Testis	262 NX

Macrophages	374 NX
Kidney	733 NX
Pancreas	639 NX
Skin	430 NX
Lung	314 NX
Prostate	243 NX
Testis	238 NX

Melanocytes	678 NX
Skin	678 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	397 NX
Pancreas	397 NX

Mucus-secreting cells	861 NX
Colon	1086 NX
Small intestine	861 NX
Rectum	790 NX

Muller glia cells	232 NX
Eye	232 NX

Pancreatic endocrine cells	704 NX
Pancreas	704 NX

Paneth cells	1273 NX
Colon	1756 NX
Small intestine	1273 NX
Rectum	915 NX

Peritubular cells	272 NX
Testis	272 NX

Proximal tubular cells	1804 NX
Kidney	1804 NX

Rod photoreceptor cells	170 NX
Eye	170 NX

Sertoli cells	181 NX
Testis	181 NX

Smooth muscle cells	457 NX
Heart muscle	821 NX
Pancreas	670 NX
Skin	401 NX
Prostate	218 NX

Spermatocytes	297 NX
Testis	297 NX

Spermatogonia	123 NX
Testis	123 NX

Suprabasal keratinocytes	449 NX
Skin	449 NX

Syncytiotrophoblasts	471 NX
Placenta	471 NX

T-cells	223 NX
Kidney	382 NX
Skin	297 NX
Lung	245 NX
Liver	219 NX
Colon	219 NX
Prostate	157 NX

Undifferentiated cells	1052 NX
Small intestine	1102 NX
Rectum	999 NX
Colon	795 NX

Urothelial cells	402 NX
Prostate	402 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.