Cell type atlas - HPGD - The Human Protein Atlas

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HPGD

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HPGD
Gene descriptionⁱ Full gene name according to HGNC.	15-hydroxyprostaglandin dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (granulocytes, Extravillous trophoblasts, Enterocytes, Urothelial cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, T-reg)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, ASC diff, HEL, RT4, SuSa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (granulocytes, Extravillous trophoblasts, Enterocytes, Urothelial cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	46 NX
Lung	46 NX

B-cells	5 NX
Liver	10 NX
Colon	6 NX
Kidney	5 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	3 NX
Eye	3 NX

Cardiomyocytes	0 NX
Heart muscle	0 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	5 NX
Lung	5 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	26 NX
Placenta	26 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	2 NX
Pancreas	2 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	1 NX
Lung	181 NX
Placenta	21 NX
Prostate	11 NX
Skin	6 NX
Pancreas	0 NX
Eye	0 NX
Heart muscle	0 NX
Testis	0 NX
Liver	0 NX

Enterocytes	274 NX
Rectum	421 NX
Small intestine	395 NX
Colon	230 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	87 NX
Pancreas	87 NX

Extravillous trophoblasts	489 NX
Placenta	489 NX

Fibroblasts	12 NX
Skin	40 NX
Lung	35 NX
Prostate	9 NX
Placenta	9 NX
Heart muscle	0 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	816 NX
Lung	1265 NX
Colon	367 NX

Hepatocytes	166 NX
Liver	166 NX

Hofbauer cells	21 NX
Placenta	21 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	8 NX
Rectum	9 NX
Colon	7 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	16 NX
Liver	16 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	11 NX
Lung	74 NX
Skin	14 NX
Kidney	11 NX
Testis	9 NX
Prostate	5 NX
Pancreas	0 NX

Melanocytes	73 NX
Skin	73 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1 NX
Pancreas	1 NX

Mucus-secreting cells	48 NX
Small intestine	106 NX
Colon	34 NX
Rectum	19 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	218 NX
Colon	409 NX
Small intestine	218 NX
Rectum	58 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	69 NX
Kidney	69 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	7 NX
Prostate	15 NX
Skin	9 NX
Heart muscle	0 NX
Pancreas	0 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	20 NX
Skin	20 NX

Syncytiotrophoblasts	47 NX
Placenta	47 NX

T-cells	50 NX
Colon	58 NX
Prostate	57 NX
Skin	53 NX
Lung	50 NX
Kidney	44 NX
Liver	24 NX

Undifferentiated cells	31 NX
Small intestine	115 NX
Colon	31 NX
Rectum	19 NX

Urothelial cells	266 NX
Prostate	266 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.